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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

Fig. 6

Brain amyloid load did not affect glucose metabolism in amyloid precursor protein/presenilin-1 (APP/PS1) mice. a, b Representative brain slices of APP/PS1 transgenic and age-matched wild-type (WT) mice were immunostained for β-amyloid (Aβ; green) and TO-PRO (blue; Thermo Fisher Scientific). c–f Cortical and hippocampal Aβ 1–42 (Aβ42) and Aβ 1–40 (Aβ40) levels measured by enzyme-linked immunosorbent assay were significantly elevated in APP/PS1 mice as compared with those in age-matched WT mice (APP/PS1 transgenic mice at age 6 months or 10–12 months, n = 3 or 4; age-matched WT mice, n = 5). g, h 2-[18F]fluoro-2-deoxy-d-glucose standardized uptake value ratios (SUVRs) in different brain regions of 6-month-old (g) and 12-month-old (h) APP/PS1 transgenic mice and age-matched controls. No significant differences were found. (n = 10 for both groups at 6 months; n = 8 for APP/PS1 mice and n = 9 for WT mice at 10–12 months). CTX Cortex, RHIP Right hippocampus, RSTR Right striatum, THA Thalamus. *P < 0.05, **P < 0.01, and ***P < 0.001

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