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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition

Fig. 2

S14 treatment enhances hippocampal cell proliferation and neurogenesis in APP/PS1 mice. a Representative images showing 5-bromo-2’-deoxyuridine-positive (BrdU+) cells in the dentate gyrus (DG) in wild-type (wt) and APP/PS1 mice. Scale bar = 20 μm. b Quantification of BrdU+ cells showing higher cell proliferation in S14-treated APP/PS1 mice compared to vehicle (Veh)-treated mice. Data are expressed as mean ± SEM; n = 9–13 mice/group; **p < 0.01. c Representative images showing BrdU+/neuronal nuclei (NeuN)+ cells in the dentate gyrus in wild-type and APP/PS1 mice. Scale bar = 20 μm. d Quantification of BrdU+/NeuN+ cells showing a significant increase in neurogenesis in both S14-treated mice groups compared to vehicle-treated mice. Data are expressed as mean ± SEM; n = 9–13 mice/group; *p < 0.05; **p < 0.01. Statistical significance was assessed by two-way ANOVA followed by Fisher’s post-hoc test for multiple comparisons

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