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Table 2 Gene-wide significant results (P < 2.7 × 10−6) from gene-based tests of pleiotropy single-nucleotide polymorphism association results

From: Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease

     Univariate gene-based tests Pleiotropy gene-based tests
Chromosome Start End Gene NP NFT CAA NP + NFT NP + CAA NFT + CAA
2 3,383,446 3,483,342 TRAPPC12 0.09 4.0 × 10−5 0.5 0.01 0.07 2.0 × 10−6
2 3,485,013 3,486,180 TRAPPC12-AS1 0.002 3.9 × 10−5 5.0 × 10−3 1.6 × 10−5 2.1 × 10−5 < 1.0 × 10−6
2 3,501,690 3,523,350 ADI1 0.003 1.6 × 10−5 7.0 × 10−4 3.2 × 10−5 4.0 × 10−6 < 1.0 × 10−6
  1. Abbreviations: NP Neuritic plaque, NFT Neurofibrillary tangles, CAA Cerebral amyloid angiopathy
  2. Gene-based P values were computed through 1 million permutations, so the smallest P value is 1.0 × 10−6