Table 2 Gene-wide significant results (P < 2.7 × 10−6) from gene-based tests of pleiotropy single-nucleotide polymorphism association results
From: Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease
Univariate gene-based tests | Pleiotropy gene-based tests | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Chromosome | Start | End | Gene | NP | NFT | CAA | NP + NFT | NP + CAA | NFT + CAA |
2 | 3,383,446 | 3,483,342 | TRAPPC12 | 0.09 | 4.0 × 10−5 | 0.5 | 0.01 | 0.07 | 2.0 × 10−6 |
2 | 3,485,013 | 3,486,180 | TRAPPC12-AS1 | 0.002 | 3.9 × 10−5 | 5.0 × 10−3 | 1.6 × 10−5 | 2.1 × 10−5 | < 1.0 × 10−6 |
2 | 3,501,690 | 3,523,350 | ADI1 | 0.003 | 1.6 × 10−5 | 7.0 × 10−4 | 3.2 × 10−5 | 4.0 × 10−6 | < 1.0 × 10−6 |