Early brain connectivity alterations and cognitive impairment in a rat model of Alzheimer’s disease

Table 2 Correlation between required training sessions and regional network metrics

	Region	Connectome	Metric	r Value
Total training sessions	L Ent Cx	FD-w	NE	−0.7708
	L Ent Cx	FD-w	CC	−0.7450
	R Pir Cx	Binary functional	NE	0.7122
	R Pir Cx	Binary functional	CC	0.7122
	R TeA Cx	FD-w	NE	−0.7056
	L IPAC, olfactory nuclei, SI, and VP	FD-w	NE	− 0.7418
	R Tu	Binary functional	NE	0.7387
	R Tu	Binary functional	CC	0.7387
	L Tu	FA-w	Strength	−0.7708
	L Pons	FD-w	CC	−0.7284
Training stage 4	L VHc and LH	Binary functional	Degree	0.7049
Training stage 5	R Amygdala	Weighted functional	Strength	−0.7797
	L Ent Cx	FD-w	NE	−0.9027
			CC	−0.8944
			Strength	−0.8333
	R Pir Cx	FD-w	NE	−0.7329
			CC	−0.7484
			Strength	−0.7070
	L RS Cx	FD-w	Strength	−0.7412
	R VCx	FD-w	NE	−0.7412
	L ADHc	Binary functional	Degree	−0.7137
	L IPAC, olfactory nuclei, SI, and VP	FD-w	NE	−0.8260
	L IPAC, olfactory nuclei, SI, and VP	FD-w	CC	−0.7450
	Left olfactory tubercle	FA-w	Strength	−0.7091
Training stage 6	R Amygdala	Binary functional	Degree	−0.7122
	L RS Cx	Weighted functional	Strength	−0.7024
	L Septum and DB	Weighted functional	NE	−0.8049

Abbreviations: NE Nodal efficiency, CC Clustering coefficient, Cx Cortex, L Left, R Right, Ent Cx Entorhinal cortex, Pir CX Piriform cortex, TeA Cx Temporal association cortex, IPAC Interstitial nucleus of the posterior limb of the anterior commissure, SI Substantia innominata, VP Ventral pallidum, Tu Olfactory tubercle, VHc Ventral hippocampus, LH Lateral hypothalamus, RS Retrosplenial cortex, VCx Visual cortex, ADHc Anterodorsal hippocampus, DB Diagonal band, FA-w Connectome weighted by fractional anisotropy, FD-w Connectome weighted by fiber density
Spearman’s correlation coefficient (r) between the number of sessions required to achieve the criteria in training stages and the regional network metrics of the structural and functional connectomes

ISSN: 1758-9193