Table 2 Sample size calculation based on the observed mean decline of the sum score within 1 year
Treatment effect | All PPA | nfvPPA | svPPA | lvPPA | ||||
|---|---|---|---|---|---|---|---|---|
Mean decline | N per group | Mean decline | N per group | Mean decline | N per group | Mean decline | N per group | |
Balanced sum score | ||||||||
10% | –4.35 | 690 | –5.82 | 712 | –3.4 | 1815 | –3.48 | 709 |
20% | –8.7 | 173 | –11.63 | 178 | –6.8 | 454 | –6.97 | 178 |
30% | –13.04 | 77 | –17.45 | 80 | –10.19 | 202 | –10.45 | 79 |
40% | –17.39 | 44 | –23.26 | 45 | –13.59 | 114 | –13.94 | 45 |
50% | –21.74 | 28 | –29.08 | 29 | –16.99 | 73 | –17.42 | 29 |
60% | –26.09 | 20 | –34.9 | 20 | –20.39 | 51 | –20.9 | 20 |
70% | –30.44 | 15 | –40.71 | 15 | –23.79 | 38 | –24.39 | 15 |
80% | –34.78 | 11 | –46.53 | 12 | –27.18 | 29 | –27.87 | 12 |
90% | –39.13 | 9 | –52.34 | 9 | –30.58 | 23 | –31.36 | 9 |
100% | –43.48 | 7 | –58.16 | 8 | –33.98 | 19 | –34.84 | 8 |
Unbalanced sum score | ||||||||
10% | –2.66 | 1110 | –3.53 | 913 | –2.14 | 1674 | –2.32 | 963 |
20% | –5.33 | 278 | –7.06 | 229 | –4.28 | 419 | –4.64 | 241 |
30% | –7.99 | 124 | –10.59 | 102 | –6.42 | 186 | –6.96 | 107 |
40% | –10.66 | 70 | –14.12 | 58 | –8.56 | 105 | –9.28 | 61 |
50% | –13.32 | 45 | –17.65 | 37 | –10.71 | 67 | –11.61 | 39 |
60% | –15.98 | 31 | –21.17 | 26 | –12.85 | 47 | –13.93 | 27 |
70% | –18.65 | 23 | –24.7 | 19 | –14.99 | 35 | –16.25 | 20 |
80% | –21.31 | 18 | –28.23 | 15 | –17.13 | 27 | –18.57 | 16 |
90% | –23.98 | 14 | –31.76 | 12 | –19.27 | 21 | –20.89 | 12 |
100% | –26.64 | 12 | –35.29 | 10 | –21.41 | 17 | –23.21 | 10 |