Table 1 Demographic variables, clinical scores, and cerebrospinal fluid biomarker values at baseline examination, separated by diagnostic group
HC | nfvPPA | svPPA | lvPPA | ||||||
|---|---|---|---|---|---|---|---|---|---|
N | Mean ± SD range | N | Mean ± SD range | N | Mean ± SD range | N | Mean ± SD range | p value | |
Gender (female/male) | 16/12 | 14/14 | 12/5 | 7/6 | 0.388 | ||||
Handedness (left/right/mix) | 1/26/1 | 3/25/0 | 1/15/1 | 1/11/1 | 0.688 | ||||
Education (years) | 27 | 13.89 ± 2.83 8–18 | 27 | 12.56 ± 3.41 4–20 | 16 | 14.69 ± 4.03 8–24 | 13 | 13 ± 3.51 8–20 | 0.140 |
Age at baseline (years) | 28 | 67.72 ± 8.08 49.8–78.7 | 28 | 67.70 ± 7.72 51.5–78.2 | 17 | 63.26 ± 6.44 53.4–77.3 | 13 | 67.03 ± 5.25 57.8–73.8 | 0.073 |
Age of initial symptoms (years) | 27 | 65.33 ± 8.35 47–78 | 14 | 58.36 ± 7.08 49–75 | 13 | 62.85 ± 5.93 54–72 | 0.022 | ||
Disease duration (years) | 27 | 2.60 ± 1.78 0.2–8.9 | 14 | 4.01 ± 1.62 1.7–6.7 | 13 | 4.18 ± 4.68 0.4–17.7 | 0.040 | ||
MMSE | 28 | 28.96 ± 0.79 27–30 | 26 | 22.73 ± 6.13 9–30 | 16 | 23.19 ± 5.47 12–30 | 13 | 20.23 ± 6.29 10–27 | 0.385 |
CDR | 28 | 0.04 ± 0.13 0–0.5 | 22 | 2.77 ± 2.87 0–13 | 14 | 3.57 ± 2.76 0.5–10 | 10 | 3.0 ± 2.93 0–8.5 | 0.461 |
FTLD-CDR | 28 | 0.05 ± 1.58 0–0.5 | 22 | 4.98 ± 3.64 0.5–18 | 14 | 5.79 ± 3.48 2.5–12.5 | 10 | 4.75 ± 3.59 1–11 | 0.561 |
Tau | 19 | 456 ± 281 139–1045 | 13 | 322 ± 125 102–493 | 7 | 651 ± 403 208–1373 | 0.194 | ||
ptau | 18 | 55 ± 30 24–141 | 13 | 47 ± 14 22–76 | 7 | 102 ± 71 16–239 | 0.091 | ||
Abeta1–42 | 19 | 585 ± 293 336–1376 | 13 | 866 ± 393 330–1601 | 7 | 525 ± 236 125–825 | 0.067 | ||