Associations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer’s disease

Table 5 Significant Relationships between peak cluster volumes and clinical parameters (Bcl-2 AA)

Seed region	frontoinsular	dLPFC	dLPFC	dLPFC
Peak cluster	Superior frontal	Superior frontal	Superior temporal pole	temporal pole
Covariance strength relationship†	G < AA	G < AA	G < AA	G < AA
MNI coordinate	(18,54,22)	(14,41,39)	(36,12,-21)	(38,12,-21)
Mini-mental state examination	0.295	0.273	0.270	0.411 ^a
T1 to T4 trial scores	0.441 ^a	0.103	0.189	0.291
30 second recalls	0.328	0.335	0.378 ^a	0.432 ^a
10 minute recalls	0.342	0.259	0.147	0.207
Modified Rey-Osterrieth Recall	0.454 ^a	0.245	0.205	0.364
Modified Rey-Osterrieth Copy	0.441 ^a	0.176	0.184	0.169
Visual object and Space Perception	0.045	0.068	-0.113	0.121
Semantic fluency: Animal	0.328	0.144	0.098	-0.005
Boston Naming Test	0.120	0.152	0.159	0.146
Comprehension	0.261	0.098	-0.022	-0.029
Digit backward	0.202	0.175	0.373	0.061
Stroop Interference Correct	0.399	0.537 ^b	0.253	0.324
Design fluency	0.363	-0.045	0.219	0.403
Trail making test time	-0.186	-0.299	-0.324	-0.520 ^b
Correct line in Trail making	0.330	0.074	0.188	0.293
Neuropsychiatric Inventory	0.190	-0.131	-0.190	-0.038

Numbers indicate Spearman’s correlation coefficient; MNI Montreal Neurological Institute ^ap < 0.05; ^b p <0.01; dLPFC dorsolateral prefrontal cortex

ISSN: 1758-9193