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Table 5 Significant Relationships between peak cluster volumes and clinical parameters (Bcl-2 AA)

From: Associations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer’s disease

Seed region frontoinsular dLPFC dLPFC dLPFC
Peak cluster Superior frontal Superior frontal Superior temporal pole temporal pole
Covariance strength relationship† G < AA G < AA G < AA G < AA
MNI coordinate (18,54,22) (14,41,39) (36,12,-21) (38,12,-21)
Mini-mental state examination 0.295 0.273 0.270 0.411 a
T1 to T4 trial scores 0.441 a 0.103 0.189 0.291
30 second recalls 0.328 0.335 0.378 a 0.432 a
10 minute recalls 0.342 0.259 0.147 0.207
Modified Rey-Osterrieth Recall 0.454 a 0.245 0.205 0.364
Modified Rey-Osterrieth Copy 0.441 a 0.176 0.184 0.169
Visual object and Space Perception 0.045 0.068 -0.113 0.121
Semantic fluency: Animal 0.328 0.144 0.098 -0.005
Boston Naming Test 0.120 0.152 0.159 0.146
Comprehension 0.261 0.098 -0.022 -0.029
Digit backward 0.202 0.175 0.373 0.061
Stroop Interference Correct 0.399 0.537 b 0.253 0.324
Design fluency 0.363 -0.045 0.219 0.403
Trail making test time -0.186 -0.299 -0.324 -0.520 b
Correct line in Trail making 0.330 0.074 0.188 0.293
Neuropsychiatric Inventory 0.190 -0.131 -0.190 -0.038
  1. Numbers indicate Spearman’s correlation coefficient; MNI Montreal Neurological Institute ap < 0.05; b p <0.01; dLPFC dorsolateral prefrontal cortex