Associations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer’s disease

Table 3 Interactions of Bcl-2 genotypes with pre-defined seed

Seed	Peak regions		Stereotaxic coordinates			Extent	Max T	P-value
Seed	Peak regions	Side	x	y	z
Right entorhinal seed (Medial Temporal Subsystem of DMN)
G- carriers < AA	Mid-occipital	R	39	-66	24	288	4.34	<0.0001
	Mid-Frontal	R	29	29	34	869	3.98	<0.0001
	Superior Frontal	R	12	14	57	255	3.97	<0.0001
Left posterior cingulate seed (Medline Subsystem of DMN)
G-carriers > AA	Cerebellum area6	L	-33	-57	-21	928	4.41	<0.0001
G-carriers > AA	Cerebellum area6	L	-23	-55	-20	1137	4.32	<0.0001
G-carriers < AA	Sub-lobar	L	-23	8	13	596	4.77	<0.0001
Right frontoinsular seed (Salience Network)
G-carriers < AA	Superior Frontal	R	18	54	22	191	3.85	<0.0001
Right dorsolateral prefrontal seed (Executive control network)
G-carriers < AA	Superior Frontal	R	14	41	39	930	4.69	<0.0001
	Superior Frontal	R	17	44	27	s.c.	4.64	<0.0001
	Superior Temporal pole	R	36	12	-21	747	4.32	<0.0001
	Superior Temporal pole	R	38	12	-21	280	3.91	<0.0001

SCN structural covariance network, DMN default mode network, s.c. same cluster

ISSN: 1758-9193