Fig. 5
Systematic sensitivity analysis of model outcome for all key parameters of the model with x0 fixed at 2. Each cell lists which of three conditions are met: Condition 1, outcome of 8.5 ± 1 points on ADAS-Cog in MCI Aβ– patients and 10.7 ± 1 points for Aβ + MCI subjects with cutoff value < 4; Condition 2, greater sensitivity to scopolamine in MCI Aβ + subjects; Condition 3, maximum difference of 10% between cognitive trajectory slopes for APOE4+/+, APOE4+/− and APOE4−/− with the additional requirement that APOE4+/+ genotype is at least 1.5 points worse than APOE4−/− at time 0 weeks. Only for some cells with δ > 0.02 and (α + α*) > 0.003 are all three conditions are met simultaneously. Note that for δ = 0 (i.e., no protective effect of the short Aβ form), no case exists where all three conditions are met simultaneously