|
Parameter
|
Value
|
|---|
|
Cmax (μg/g plasma)
|
10.90
|
|
Tmax (h)
|
3.00
|
|
AUC48h (μg h/ml)
|
89.58
|
|
T1/2 (h)
|
3.24
|
|
CL (ml/min/kg)
|
2.23
|
|
Vd (L/kg)
|
0.63
|
- Plasma levels of MH84 were determined using HPCL after single oral gavage of 12 mg/kg MH84. The following pharmacokinetic parameters were adopted from our previous publication (for details, please refer to Pellowska et al. [35]): Cmax, maximum concentration; Tmax, time to reach Cmax; AUC48h, area under the curve until 48 h; T1/2, half-life time; CL, clearance; Vd, volume of distribution
- MH84 ethyl 2-(4,6-bis(4-(trifluoromethyl)phenethoxy)pyrimidin-2-yl-thio)hexanoate
