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Table 1 Pharmacokinetic parameters of MH84

From: MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer’s disease

Parameter Value
Cmax (μg/g plasma) 10.90
Tmax (h) 3.00
AUC48h (μg h/ml) 89.58
T1/2 (h) 3.24
CL (ml/min/kg) 2.23
Vd (L/kg) 0.63
  1. Plasma levels of MH84 were determined using HPCL after single oral gavage of 12 mg/kg MH84. The following pharmacokinetic parameters were adopted from our previous publication (for details, please refer to Pellowska et al. [35]): Cmax, maximum concentration; Tmax, time to reach Cmax; AUC48h, area under the curve until 48 h; T1/2, half-life time; CL, clearance; Vd, volume of distribution
  2. MH84 ethyl 2-(4,6-bis(4-(trifluoromethyl)phenethoxy)pyrimidin-2-yl-thio)hexanoate