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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer’s disease

Fig. 2

Brain levels of full-length amyloid precursor protein (a, b fl-AβPP) and its α-secretase and β-secretase cleavage products C83 and C99, respectively (b, c, d) detected using western blot techniques. Data represent means ± SEM from eight experiments; one-way ANOVA with Tukey’s multiple comparison post test (*p < 0.05, **p < 0.01, ***p < 0.001 against wild-type(control); +++p < 0.001 against Thy-1 AβPPSL (control)). Levels of soluble human β-amyloid peptides (e Aβ40 and f Aβ42) were determined using ELISA. Data represent means ± SEM. N = 11 (six females, five males); Student’s unpaired t test (**p < 0.01 against Thy-1 AβPPSL (control)). AβPP beta-amyloid precursor protein, Aβ amyloid-beta

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