TY - JOUR AU - Glenner, G. G. AU - Wong, C. W. PY - 1984 DA - 1984// TI - Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein JO - Biochem Biophys Res Commun VL - 120 UR - https://doi.org/10.1016/S0006-291X(84)80190-4 DO - 10.1016/S0006-291X(84)80190-4 ID - Glenner1984 ER - TY - JOUR AU - Grundke-Iqbal, I. AU - Iqbal, K. AU - Tung, Y. C. AU - Quinlan, M. AU - Wisniewski, H. M. AU - Binder, L. I. PY - 1986 DA - 1986// TI - Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology JO - Proc Natl Acad Sci U S A VL - 83 UR - https://doi.org/10.1073/pnas.83.13.4913 DO - 10.1073/pnas.83.13.4913 ID - Grundke-Iqbal1986 ER - TY - JOUR AU - Avila, J. AU - Lucas, J. J. AU - Perez, M. AU - Hernandez, F. PY - 2004 DA - 2004// TI - Role of tau protein in both physiological and pathological conditions JO - Physiol Rev VL - 84 UR - https://doi.org/10.1152/physrev.00024.2003 DO - 10.1152/physrev.00024.2003 ID - Avila2004 ER - TY - JOUR AU - Alonso, A. C. AU - Zaidi, T. AU - Grundke-Iqbal, I. AU - Iqbal, K. PY - 1994 DA - 1994// TI - Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease JO - Proc Natl Acad Sci U S A VL - 91 UR - https://doi.org/10.1073/pnas.91.12.5562 DO - 10.1073/pnas.91.12.5562 ID - Alonso1994 ER - TY - JOUR AU - Alonso, A. AU - Zaidi, T. AU - Novak, M. AU - Grundke-Iqbal, I. AU - Iqbal, K. PY - 2001 DA - 2001// TI - Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments JO - Proc Natl Acad Sci U S A VL - 98 UR - https://doi.org/10.1073/pnas.121119298 DO - 10.1073/pnas.121119298 ID - Alonso2001 ER - TY - JOUR AU - Alonso, A. C. AU - Grundke-Iqbal, I. AU - Iqbal, K. PY - 1996 DA - 1996// TI - Alzheimer’s disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules JO - Nat Med VL - 2 UR - https://doi.org/10.1038/nm0796-783 DO - 10.1038/nm0796-783 ID - Alonso1996 ER - TY - JOUR AU - Braak, H. AU - Braak, E. PY - 1991 DA - 1991// TI - Neuropathological stageing of Alzheimer-related changes JO - Acta Neuropathol VL - 82 UR - https://doi.org/10.1007/BF00308809 DO - 10.1007/BF00308809 ID - Braak1991 ER - TY - JOUR AU - Braak, H. AU - Tredici, K. PY - 2011 DA - 2011// TI - The pathological process underlying Alzheimer’s disease in individuals under thirty JO - Acta Neuropathol VL - 121 UR - https://doi.org/10.1007/s00401-010-0789-4 DO - 10.1007/s00401-010-0789-4 ID - Braak2011 ER - TY - JOUR AU - Clavaguera, F. AU - Bolmont, T. AU - Crowther, R. A. AU - Abramowski, D. AU - Frank, S. AU - Probst, A. PY - 2009 DA - 2009// TI - Transmission and spreading of tauopathy in transgenic mouse brain JO - Nat Cell Biol VL - 11 UR - https://doi.org/10.1038/ncb1901 DO - 10.1038/ncb1901 ID - Clavaguera2009 ER - TY - JOUR AU - Clavaguera, F. AU - Akatsu, H. AU - Fraser, G. AU - Crowther, R. A. AU - Frank, S. AU - Hench, J. PY - 2013 DA - 2013// TI - Brain homogenates from human tauopathies induce tau inclusions in mouse brain JO - Proc Natl Acad Sci U S A VL - 110 UR - https://doi.org/10.1073/pnas.1301175110 DO - 10.1073/pnas.1301175110 ID - Clavaguera2013 ER - TY - JOUR AU - Iba, M. AU - Guo, J. L. AU - McBride, J. D. AU - Zhang, B. AU - Trojanowski, J. Q. AU - Lee, V. M. PY - 2013 DA - 2013// TI - Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer’s-like tauopathy JO - J Neurosci VL - 33 UR - https://doi.org/10.1523/JNEUROSCI.2642-12.2013 DO - 10.1523/JNEUROSCI.2642-12.2013 ID - Iba2013 ER - TY - JOUR AU - Liu, L. AU - Drouet, V. AU - Wu, J. W. AU - Witter, M. P. AU - Small, S. A. AU - Clelland, C. PY - 2012 DA - 2012// TI - Trans-synaptic spread of tau pathology in vivo JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0031302 DO - 10.1371/journal.pone.0031302 ID - Liu2012 ER - TY - JOUR AU - Calignon, A. AU - Polydoro, M. AU - Suarez-Calvet, M. AU - William, C. AU - Adamowicz, D. H. AU - Kopeikina, K. J. PY - 2012 DA - 2012// TI - Propagation of tau pathology in a model of early Alzheimer’s disease JO - Neuron VL - 73 UR - https://doi.org/10.1016/j.neuron.2011.11.033 DO - 10.1016/j.neuron.2011.11.033 ID - Calignon2012 ER - TY - JOUR AU - Frost, B. AU - Jacks, R. L. AU - Diamond, M. I. PY - 2009 DA - 2009// TI - Propagation of tau misfolding from the outside to the inside of a cell JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.M808759200 DO - 10.1074/jbc.M808759200 ID - Frost2009 ER - TY - JOUR AU - Sankaranarayanan, S. AU - Barten, D. M. AU - Vana, L. AU - Devidze, N. AU - Yang, L. AU - Cadelina, G. PY - 2015 DA - 2015// TI - Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models JO - PLoS One VL - 10 UR - https://doi.org/10.1371/journal.pone.0125614 DO - 10.1371/journal.pone.0125614 ID - Sankaranarayanan2015 ER - TY - JOUR AU - Yanamandra, K. AU - Kfoury, N. AU - Jiang, H. AU - Mahan, T. E. AU - Ma, S. AU - Maloney, S. E. PY - 2013 DA - 2013// TI - Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo JO - Neuron VL - 80 UR - https://doi.org/10.1016/j.neuron.2013.07.046 DO - 10.1016/j.neuron.2013.07.046 ID - Yanamandra2013 ER - TY - JOUR AU - Hu, W. AU - Zhang, X. AU - Tung, Y. C. AU - Xie, S. AU - Liu, F. AU - Iqbal, K. PY - 2016 DA - 2016// TI - Hyperphosphorylation determines both the spread and the morphology of tau pathology JO - Alzheimers Dement VL - 12 UR - https://doi.org/10.1016/j.jalz.2016.01.014 DO - 10.1016/j.jalz.2016.01.014 ID - Hu2016 ER - TY - JOUR AU - Dai, C. L. AU - Tung, Y. C. AU - Liu, F. AU - Gong, C. X. AU - Iqbal, K. PY - 2017 DA - 2017// TI - Tau passive immunization inhibits not only tau but also Aβ pathology JO - Alzheimers Res Ther VL - 9 UR - https://doi.org/10.1186/s13195-016-0227-5 DO - 10.1186/s13195-016-0227-5 ID - Dai2017 ER - TY - JOUR AU - Dai, C. L. AU - Chen, X. AU - Liu, F. AU - Gong, C. X. AU - Grundke-Iqbal, I. AU - Iqbal, K. PY - 2015 DA - 2015// TI - Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies JO - J Neural Transm (Vienna) VL - 122 UR - https://doi.org/10.1007/s00702-014-1315-y DO - 10.1007/s00702-014-1315-y ID - Dai2015 ER - TY - JOUR AU - Oddo, S. AU - Caccamo, A. AU - Shepherd, J. D. AU - Murphy, M. P. AU - Golde, T. E. AU - Kayed, R. PY - 2003 DA - 2003// TI - Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Aβ and synaptic dysfunction JO - Neuron VL - 39 UR - https://doi.org/10.1016/S0896-6273(03)00434-3 DO - 10.1016/S0896-6273(03)00434-3 ID - Oddo2003 ER - TY - JOUR AU - Blanchard, J. AU - Wanka, L. AU - Tung, Y. C. AU - Carmen, C. -. A. M. AU - LaFerla, F. M. AU - Iqbal, K. PY - 2010 DA - 2010// TI - Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice JO - Acta Neuropathol VL - 120 UR - https://doi.org/10.1007/s00401-010-0734-6 DO - 10.1007/s00401-010-0734-6 ID - Blanchard2010 ER - TY - JOUR AU - Kazim, S. F. AU - Blanchard, J. AU - Dai, C. L. AU - Tung, Y. C. AU - LaFerla, F. M. AU - Iqbal, K. PY - 2014 DA - 2014// TI - Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer’s disease JO - Neurobiol Dis VL - 71 UR - https://doi.org/10.1016/j.nbd.2014.07.001 DO - 10.1016/j.nbd.2014.07.001 ID - Kazim2014 ER - TY - JOUR AU - Carroll, J. C. AU - Rosario, E. R. AU - Kreimer, S. AU - Villamagna, A. AU - Gentzschein, E. AU - Stanczyk, F. Z. PY - 2010 DA - 2010// TI - Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure JO - Brain Res VL - 1366 UR - https://doi.org/10.1016/j.brainres.2010.10.009 DO - 10.1016/j.brainres.2010.10.009 ID - Carroll2010 ER - TY - JOUR AU - Hirata-Fukae, C. AU - Li, H. F. AU - Hoe, H. S. AU - Gray, A. J. AU - Minami, S. S. AU - Hamada, K. PY - 2008 DA - 2008// TI - Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model JO - Brain Res VL - 1216 UR - https://doi.org/10.1016/j.brainres.2008.03.079 DO - 10.1016/j.brainres.2008.03.079 ID - Hirata-Fukae2008 ER - TY - JOUR AU - Clinton, L. K. AU - Billings, L. M. AU - Green, K. N. AU - Caccamo, A. AU - Ngo, J. AU - Oddo, S. PY - 2007 DA - 2007// TI - Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice JO - Neurobiol Dis VL - 28 UR - https://doi.org/10.1016/j.nbd.2007.06.013 DO - 10.1016/j.nbd.2007.06.013 ID - Clinton2007 ER - TY - JOUR AU - Rodriguez, J. J. AU - Jones, V. C. AU - Tabuchi, M. AU - Allan, S. M. AU - Knight, E. M. AU - LaFerla, F. M. PY - 2008 DA - 2008// TI - Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer’s disease JO - PLoS One VL - 3 UR - https://doi.org/10.1371/journal.pone.0002935 DO - 10.1371/journal.pone.0002935 ID - Rodriguez2008 ER - TY - JOUR AU - Kopke, E. AU - Tung, Y. C. AU - Shaikh, S. AU - Alonso, A. C. AU - Iqbal, K. AU - Grundke-Iqbal, I. PY - 1993 DA - 1993// TI - Microtubule-associated protein tau: abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease JO - J Biol Chem VL - 268 ID - Kopke1993 ER - TY - JOUR AU - Urbanc, B. AU - Cruz, L. AU - Le, R. AU - Sanders, J. AU - Ashe, K. H. AU - Duff, K. PY - 2002 DA - 2002// TI - Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer’s disease JO - Proc Natl Acad Sci U S A VL - 99 UR - https://doi.org/10.1073/pnas.222433299 DO - 10.1073/pnas.222433299 ID - Urbanc2002 ER - TY - JOUR AU - Sun, A. AU - Nguyen, X. V. AU - Bing, G. PY - 2002 DA - 2002// TI - Comparative analysis of an improved thioflavin-S stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections JO - J Histochem Cytochem VL - 50 UR - https://doi.org/10.1177/002215540205000403 DO - 10.1177/002215540205000403 ID - Sun2002 ER - TY - JOUR AU - Shah, D. K. AU - Betts, A. M. PY - 2013 DA - 2013// TI - Antibody biodistribution coefficients: inferring tissue concentrations of monoclonal antibodies based on the plasma concentrations in several preclinical species and human JO - MAbs VL - 5 UR - https://doi.org/10.4161/mabs.23684 DO - 10.4161/mabs.23684 ID - Shah2013 ER - TY - JOUR AU - Wang, W. AU - Wang, E. Q. AU - Balthasar, J. P. PY - 2008 DA - 2008// TI - Monoclonal antibody pharmacokinetics and pharmacodynamics JO - Clin Pharmacol Ther VL - 84 UR - https://doi.org/10.1038/clpt.2008.170 DO - 10.1038/clpt.2008.170 ID - Wang2008 ER - TY - JOUR AU - Vieira, P. AU - Rajewsky, K. PY - 1986 DA - 1986// TI - The bulk of endogenously produced IgG2a is eliminated from the serum of adult C57BL/6 mice with a half-life of 6-8 days JO - Eur J Immunol VL - 16 UR - https://doi.org/10.1002/eji.1830160727 DO - 10.1002/eji.1830160727 ID - Vieira1986 ER - TY - JOUR AU - Agadjanyan, M. G. AU - Zagorski, K. AU - Petrushina, I. AU - Davtyan, H. AU - Kazarian, K. AU - Antonenko, M. PY - 2017 DA - 2017// TI - Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency JO - Mol Neurodegener VL - 12 UR - https://doi.org/10.1186/s13024-017-0172-1 DO - 10.1186/s13024-017-0172-1 ID - Agadjanyan2017 ER - TY - JOUR AU - Collin, L. AU - Bohrmann, B. AU - Gopfert, U. AU - Oroszlan-Szovik, K. AU - Ozmen, L. AU - Gruninger, F. PY - 2014 DA - 2014// TI - Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer’s disease JO - Brain VL - 137 UR - https://doi.org/10.1093/brain/awu213 DO - 10.1093/brain/awu213 ID - Collin2014 ER - TY - JOUR AU - Chai, X. AU - Wu, S. AU - Murray, T. K. AU - Kinley, R. AU - Cella, C. V. AU - Sims, H. PY - 2011 DA - 2011// TI - Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression JO - J Biol Chem VL - 286 UR - https://doi.org/10.1074/jbc.M111.229633 DO - 10.1074/jbc.M111.229633 ID - Chai2011 ER - TY - JOUR AU - Lee, S. H. AU - Pichon, C. E. AU - Adolfsson, O. AU - Gafner, V. AU - Pihlgren, M. AU - Lin, H. PY - 2016 DA - 2016// TI - Antibody-mediated targeting of tau in vivo does not require effector function and microglial engagement JO - Cell Rep VL - 16 UR - https://doi.org/10.1016/j.celrep.2016.06.099 DO - 10.1016/j.celrep.2016.06.099 ID - Lee2016 ER - TY - JOUR AU - Umeda, T. AU - Eguchi, H. AU - Kunori, Y. AU - Matsumoto, Y. AU - Taniguchi, T. AU - Mori, H. PY - 2015 DA - 2015// TI - Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice JO - Ann Clin Transl Neurol VL - 2 UR - https://doi.org/10.1002/acn3.171 DO - 10.1002/acn3.171 ID - Umeda2015 ER - TY - JOUR AU - Boutajangout, A. AU - Ingadottir, J. AU - Davies, P. AU - Sigurdsson, E. M. PY - 2011 DA - 2011// TI - Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain JO - J Neurochem VL - 118 UR - https://doi.org/10.1111/j.1471-4159.2011.07337.x DO - 10.1111/j.1471-4159.2011.07337.x ID - Boutajangout2011 ER - TY - JOUR AU - Castillo-Carranza, D. L. AU - Sengupta, U. AU - Guerrero-Muñoz, M. J. AU - Lasagna-Reeves, C. A. AU - Gerson, J. E. AU - Singh, G. PY - 2014 DA - 2014// TI - Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles JO - J Neurosci VL - 34 UR - https://doi.org/10.1523/JNEUROSCI.3192-13.2014 DO - 10.1523/JNEUROSCI.3192-13.2014 ID - Castillo-Carranza2014 ER - TY - JOUR AU - Ahmed, Z. AU - Cooper, J. AU - Murray, T. K. AU - Garn, K. AU - McNaughton, E. AU - Clarke, H. PY - 2014 DA - 2014// TI - A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity JO - Acta Neuropathol VL - 127 UR - https://doi.org/10.1007/s00401-014-1254-6 DO - 10.1007/s00401-014-1254-6 ID - Ahmed2014 ER - TY - JOUR AU - Takeda, S. AU - Wegmann, S. AU - Cho, H. AU - DeVos, S. L. AU - Commins, C. AU - Roe, A. D. PY - 2015 DA - 2015// TI - Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain JO - Nat Commun VL - 6 UR - https://doi.org/10.1038/ncomms9490 DO - 10.1038/ncomms9490 ID - Takeda2015 ER - TY - JOUR AU - Boluda, S. AU - Iba, M. AU - Zhang, B. AU - Raible, K. M. AU - Lee, V. M. AU - Trojanowski, J. Q. PY - 2015 DA - 2015// TI - Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains JO - Acta Neuropathol VL - 129 UR - https://doi.org/10.1007/s00401-014-1373-0 DO - 10.1007/s00401-014-1373-0 ID - Boluda2015 ER - TY - JOUR AU - Peeraer, E. AU - Bottelbergs, A. AU - Kolen, K. AU - Stancu, I. C. AU - Vasconcelos, B. AU - Mahieu, M. PY - 2015 DA - 2015// TI - Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice JO - Neurobiol Dis VL - 73 UR - https://doi.org/10.1016/j.nbd.2014.08.032 DO - 10.1016/j.nbd.2014.08.032 ID - Peeraer2015 ER - TY - JOUR AU - Lasagna-Reeves, C. A. AU - Castillo-Carranza, D. L. AU - Sengupta, U. AU - Guerrero-Munoz, M. J. AU - Kiritoshi, T. AU - Neugebauer, V. PY - 2012 DA - 2012// TI - Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau JO - Sci Rep VL - 2 UR - https://doi.org/10.1038/srep00700 DO - 10.1038/srep00700 ID - Lasagna-Reeves2012 ER - TY - JOUR AU - Chai, X. AU - Dage, J. L. AU - Citron, M. PY - 2012 DA - 2012// TI - Constitutive secretion of tau protein by an unconventional mechanism JO - Neurobiol Dis VL - 48 UR - https://doi.org/10.1016/j.nbd.2012.05.021 DO - 10.1016/j.nbd.2012.05.021 ID - Chai2012 ER - TY - JOUR AU - Pooler, A. M. AU - Phillips, E. C. AU - Lau, D. H. AU - Noble, W. AU - Hanger, D. P. PY - 2013 DA - 2013// TI - Physiological release of endogenous tau is stimulated by neuronal activity JO - EMBO Rep VL - 14 UR - https://doi.org/10.1038/embor.2013.15 DO - 10.1038/embor.2013.15 ID - Pooler2013 ER - TY - JOUR AU - Yamada, K. AU - Holth, J. K. AU - Liao, F. AU - Stewart, F. R. AU - Mahan, T. E. AU - Jiang, H. PY - 2014 DA - 2014// TI - Neuronal activity regulates extracellular tau in vivo JO - J Exp Med VL - 211 UR - https://doi.org/10.1084/jem.20131685 DO - 10.1084/jem.20131685 ID - Yamada2014 ER - TY - JOUR AU - Bright, J. AU - Hussain, S. AU - Dang, V. AU - Wright, S. AU - Cooper, B. AU - Byun, T. PY - 2015 DA - 2015// TI - Human secreted tau increases amyloid-β production JO - Neurobiol Aging VL - 36 UR - https://doi.org/10.1016/j.neurobiolaging.2014.09.007 DO - 10.1016/j.neurobiolaging.2014.09.007 ID - Bright2015 ER - TY - JOUR AU - Meredith, J. E. AU - Sankaranarayanan, S. AU - Guss, V. AU - Lanzetti, A. J. AU - Berisha, F. AU - Neely, R. J. PY - 2013 DA - 2013// TI - Characterization of novel CSF Tau and ptau biomarkers for Alzheimer’s disease JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0076523 DO - 10.1371/journal.pone.0076523 ID - Meredith2013 ER - TY - JOUR AU - Congdon, E. E. AU - Gu, J. AU - Sait, H. B. AU - Sigurdsson, E. M. PY - 2013 DA - 2013// TI - Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.491001 DO - 10.1074/jbc.M113.491001 ID - Congdon2013 ER - TY - JOUR AU - Gu, J. AU - Congdon, E. E. AU - Sigurdsson, E. M. PY - 2013 DA - 2013// TI - Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.494922 DO - 10.1074/jbc.M113.494922 ID - Gu2013 ER - TY - JOUR AU - McEwan, W. A. AU - Falcon, B. AU - Vaysburd, M. AU - Clift, D. AU - Oblak, A. L. AU - Ghetti, B. PY - 2017 DA - 2017// TI - Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation JO - Proc Natl Acad Sci U S A VL - 114 UR - https://doi.org/10.1073/pnas.1607215114 DO - 10.1073/pnas.1607215114 ID - McEwan2017 ER - TY - JOUR AU - Wang, Y. AU - Mandelkow, E. PY - 2016 DA - 2016// TI - Tau in physiology and pathology JO - Nat Rev Neurosci VL - 17 UR - https://doi.org/10.1038/nrn.2015.1 DO - 10.1038/nrn.2015.1 ID - Wang2016 ER - TY - JOUR AU - Pedersen, J. T. AU - Sigurdsson, E. M. PY - 2015 DA - 2015// TI - Tau immunotherapy for Alzheimer’s disease JO - Trends Mol Med VL - 21 UR - https://doi.org/10.1016/j.molmed.2015.03.003 DO - 10.1016/j.molmed.2015.03.003 ID - Pedersen2015 ER - TY - JOUR AU - Hardy, J. AU - Selkoe, D. J. PY - 2002 DA - 2002// TI - The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics JO - Science VL - 297 UR - https://doi.org/10.1126/science.1072994 DO - 10.1126/science.1072994 ID - Hardy2002 ER - TY - JOUR AU - Braak, H. AU - Braak, E. PY - 1997 DA - 1997// TI - Frequency of stages of Alzheimer-related lesions in different age categories JO - Neurobiol Aging VL - 18 UR - https://doi.org/10.1016/S0197-4580(97)00056-0 DO - 10.1016/S0197-4580(97)00056-0 ID - Braak1997 ER - TY - JOUR AU - Braak, H. AU - Zetterberg, H. AU - Tredici, K. AU - Blennow, K. PY - 2013 DA - 2013// TI - Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid JO - Acta Neuropathol VL - 126 UR - https://doi.org/10.1007/s00401-013-1139-0 DO - 10.1007/s00401-013-1139-0 ID - Braak2013 ER - TY - JOUR AU - Rajamohamedsait, H. AU - Rasool, S. AU - Rajamohamedsait, W. AU - Lin, Y. AU - Sigurdsson, E. M. PY - 2017 DA - 2017// TI - Prophylactic active tau immunization leads to sustained reduction in both tau and amyloid-β pathologies in 3xTg mice JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/s41598-017-17313-1 DO - 10.1038/s41598-017-17313-1 ID - Rajamohamedsait2017 ER - TY - JOUR AU - Bonifati, D. M. AU - Kishore, U. PY - 2007 DA - 2007// TI - Role of complement in neurodegeneration and neuroinflammation JO - Mol Immunol VL - 44 UR - https://doi.org/10.1016/j.molimm.2006.03.007 DO - 10.1016/j.molimm.2006.03.007 ID - Bonifati2007 ER - TY - JOUR AU - Pisalyaput, K. AU - Tenner, A. J. PY - 2008 DA - 2008// TI - Complement component C1q inhibits β-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms JO - J Neurochem VL - 104 ID - Pisalyaput2008 ER - TY - JOUR AU - Wyss-Coray, T. AU - Yan, F. AU - Lin, A. H. AU - Lambris, J. D. AU - Alexander, J. J. AU - Quigg, R. J. PY - 2002 DA - 2002// TI - Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer’s mice JO - Proc Natl Acad Sci U S A VL - 99 UR - https://doi.org/10.1073/pnas.162350199 DO - 10.1073/pnas.162350199 ID - Wyss-Coray2002 ER - TY - JOUR AU - Maier, M. AU - Peng, Y. AU - Jiang, L. AU - Seabrook, T. J. AU - Carroll, M. C. AU - Lemere, C. A. PY - 2008 DA - 2008// TI - Complement C3 deficiency leads to accelerated amyloid β plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice JO - J Neurosci VL - 28 UR - https://doi.org/10.1523/JNEUROSCI.0829-08.2008 DO - 10.1523/JNEUROSCI.0829-08.2008 ID - Maier2008 ER - TY - JOUR AU - Fu, H. AU - Liu, B. AU - Frost, J. L. AU - Hong, S. AU - Jin, M. AU - Ostaszewski, B. PY - 2012 DA - 2012// TI - Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia JO - Glia VL - 60 UR - https://doi.org/10.1002/glia.22331 DO - 10.1002/glia.22331 ID - Fu2012 ER - TY - JOUR AU - Choucair-Jaafar, N. AU - Laporte, V. AU - Levy, R. AU - Poindron, P. AU - Lombard, Y. AU - Gies, J. P. PY - 2011 DA - 2011// TI - Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides JO - Fundam Clin Pharmacol VL - 25 UR - https://doi.org/10.1111/j.1472-8206.2010.00811.x DO - 10.1111/j.1472-8206.2010.00811.x ID - Choucair-Jaafar2011 ER -