Skip to main content
Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial

Fig. 4

Reactivity of ABvac40-induced anti-amyloid-β (anti-Aβ) antibodies: a Post-immune plasma samples (week 10) from an ABvac40-treated patient (S013) recognised different forms of synthetic Aβ40 peptide (lane 1). In contrast, they did not label any form of synthetic Aβ42 (lane 2). Pre-immune plasma (week 0) did not show reactivity with Aβ40 or Aβ42. b and c Binding of plasma samples from the same patient (S013; week 10) to amyloid plaques in paraffin-embedded brain sections from APP/PS1-transgenic mice (b) and patients with AD (c). Pre-adsorption of plasma with Aβ33–40 peptide prevented plaque staining. Specific anti-Aβ40 polyclonal antibody was used as a positive control. Scale bar = 100 μm

Back to article page