Table 1 Main characteristics of IDD patients

Age (years)

38.7 ± 11.1; 37 (21–69)

46 ± 5.9; 47 (37–54)

38.3 ± 11.5; 38 (21–65)

36.7 ± 9.9; 35.5 (22–69)

46.6 ± 14.3; 44.5 (29–66)

0.038

Female/male

2.5 (69/28)

2 (4/2)

1.7 (20/12)

3.3 (39/12)

3 (6/2)

0.624

Recent relapse^a

64 (65.9%)

0

27 (84.4%)

36 (70.6%)

1 (12.5%)

< 0.001

Time from clinical onset (years)

2.7 ± 4.9; 0.3 (0.001–29)

–

0.3 ± 1; 0.04 (0–5)

3.8 ± 6; 1 (0.01–29)

5.1 ± 3.3; 4.5 (2–10)

0.010

EDSS

2.2 ± 1.3; 2 (0–7)

1.1 ± 0.6; 1 (0–2)

1.9 ± 0.8; 2 (1–4)

2.2 ± 1.2; 2 (0–7)

4.7 ± 1.7; 4.5 (3–7)

< 0.001

OCB+

68 (70.1%)

4 (66.7%)

19 (59.4%)

37 (72.5%)

8 (100%)

0.040

T2 lesions (n)

9.4 ± 7.2; 8 (1–39)

6.1 ± 3.6; 5 (3–11)

6.2 ± 4.7; 5 (1–18)

11.6 ± 6.3; 10 (2–36)

18.6 ± 11; 16 (7–39)

< 0.001

0–3 T2 lesions

21 (21.6%)

1 (16.7%)

11 (34.4%)

10 (19.6%)

0

< 0.001

4–9 T2 lesions

36 (37.1%)

3 (50%)

15 (46.9%)

15 (29.4%)

2 (25%)

>9 T2 lesions

40 (41.2%)

2 (33.6%)

6 (18.7%)

26 (51%)

6 (75%)

Juxtacortical lesions (n)

2.2 ± 2.1; 2 (0–9)

2 ± 1.2; 2 (0–3)

1.4 ± 1.8; 1 (0–6)

2.5 ± 2; 3 (0–9)

3.7 ± 3.5; 4 (0–9)

0.011

Periventricular lesions (n)

5 ± 3.2; 5 (0–15)

3.4 ± 2.6; 3 (0–7)

3.5 ± 3; 3 (0–10)

5.7 ± 2.7; 6 (0–12)

8.4 ± 3.8; 9 (2–15)

< 0.001

Infratentorial lesions (n)

1.1 ± 1.5; 0.5 (0–6)

0

0.5 ± 0.9; 0 (0–4)

1.4 ± 1.6; 1 (0–6)

2.6 ± 2.1; 2 (0–6)

< 0.001

Spinal cord lesions (n)

1.4 ± 2; 1 (0–9)

0.6 ± 1; 0 (0–2)

0.7 ± 1; 1 (0–5)

1.7 ± 2.1; 1 (0–9)

3.9 ± 3.1; 4 (0–9)

< 0.001

Gd + lesions (n)

1.4 ± 2.4; 1 (0–14)

0.3 ± 0.5; 0 (0–1)

0.6 ± 0.5; 1 (0–1)

2.2 ± 3; 1 (0–14)

0.1 ± 0.4; 0 (0–1)

0.004

0 Gd + lesions

43 (44.3%)

4 (66.7%)

12 (37.5%)

20 (39.2%)

7 (87.5%)

< 0.001

1–3 Gd + lesions

45 (46.4%)

2 (33.3%)

20 (62.5%)

22 (43.2%)

1 (12.5%)

>3 Gd + lesions

9 (9.3%)

0

0

9 (17.6%)

0

CSF NfL (pg/ml)

881 ± 941; 639 (68–5748)

438 ± 262; 321 (198–795)

791 ± 687; 631 (156–3492)

1028 ± 1157; 642 (136–5748)

1066 ± 904; 825 (350–3065)

0.345