Fig. 2

CSF NfL values (pg/ml) in the different diagnostic groups. a CSF neurofilament light (NfL) values in IDD, MCI-AD/AD-dem, PD, and OND groups; p values are from the ANCOVA adjusted for age and sex; *p < 0.05; **p < 0.01; ***p < 0.001. b Diagnostic value of CSF NfL. IDD vs OND comparison (age-adjusted AUC = 0.87, 95% CI 0.80–0.95) is reported as the solid line. MCI-AD/AD-dem vs OND comparison (age-adjusted AUC = 0.84, 95% CI 0.74–0.95) is reported as the dashed line. PD vs OND comparison (age-adjusted AUC = 0.69, 95% CI 0.56–0.81) is reported as the dotted line. AD-dem Alzheimer’s disease dementia, IDD inflammatory diseases of the central nervous system, MCI-AD mild cognitive impairment due to Alzheimer’s disease, OND other neurological diseases, PD Parkinson’s disease