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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer’s disease

Fig. 6

Longitudinal analysis of kallikrein 6 (KLK6) among patient groups as well as among apolipoprotein E (APOE) ε4 carriers and non-carriers. a, b Multivariate analysis of variance (MANOVA) plots show vector graphs taking least squares (LS) mean values from each category (green lines = patients with mild cognitive impairment that remained unchanged over 24 months [MCI-MCI]; blue lines = patients with mild cognitive impairment who developed Alzheimer’s disease [MCI-AD]; red lines = patients diagnosed with Alzheimer’s disease at inclusion [AD-AD]) in the y-axis over three time points (T0, T12 and T24, representing baseline and after 12 and 24 months, respectively). c, d MANOVA plots between subjects grouped as APOE ε4 carriers (red lines) and non-carriers (green lines). Significant alterations are reported with p values after Bonferroni correction (n = 3 comparisons) derived from pairwise comparisons between T0 and T12 and between T12 and T24 by Student’s t test. NS Not significant

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