Skip to main content

Table 3 Cerebral small vessel disease and its clinicopathological correlation

From: Extended FTLD pedigree segregating a Belgian GRN-null mutation: neuropathological heterogeneity in one family

Identifier

Frontal

Temporal

Hippocampal

Basal ganglia

Total score

CAA

Large infarcts

Arteriolosclerosis

Correlation

DR2.3

1

1

1

2

5

0

0

0

Low

DR8.1

2

2

2

1

7

1

0

1

Low

DR25.1

2

1

2

1

6

0

0

0

Low

DR25.5

2

2

1

1

6

0

0

2

Low

DR28.1

1

1

1

1

4

0

0

1

Low

DR205.1

NA

NA

2

1

NA

NA

NA

NA

Low

DR31.1

2

1

1

1

5

0

0

1

Low

DR1207.1

2

1

1

1

5

0

0

1

Low

DR1213.1

1

1

1

2

5

0

0

0

Low

  1. CAA Leptomeningeal cerebral amyloid angiopathy, NA Not applicable
  2. Deramecourt staging of cerebrovascular pathology in dementia in frontal lobe, temporal lobe, and hippocampus, with total score (total possible score = 20) [36]. For the likelihood that cerebral small vessel disease (SVD) contributed to cognitive decline, we refer to the work of Skrobot et al. [41]. Large infarcts: one or more subcortical infarcts with diameter > 10 mm; arteriolosclerosis: arteriolosclerosis in the occipital lobe. Correlation: likelihood that SVD contributed to cognitive decline
Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193