Fig. 1

Macroscopic images. a Lateral view of the right hemisphere in DR2.3. Note the frontal and temporal, and to a lesser extent parietal, atrophy. Area 4 (arrow) is relatively preserved. b Medial view of right hemisphere in DR2.3. The superior frontal gyrus is atrophied, whereas the straight gyrus is relatively spared. c Coronal section of the right hemisphere trough the head of the caudate nucleus in DR2.3. There is a flattened, nearly concave aspect of the caudate nucleus. d Coronal sections trough the parietotemporal lobes in DR8.1. The lateral ventricle is dilated, especially the temporal horn. Temporal atrophy is more pronounced than parietal atrophy