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Table 2 Radiological findings in carriers of MAPT R406W

From: Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

 

ID

Sex

Modality (n)

DD, years

Atrophy pattern

Temporal lobe atrophy

Hippocampus

Parahippocampal gyrus

Collateral sulcus

Symmetry

Vascular pathology

Quality

Present study

III-1

F

(1) CT

2

T

M 2a

   

L > R

0b

–c

III-3

F

(1) CT

28

General

2a

 

Advanced atrophy

 

Yes

2b

–c

III-5

M

(1) CT

6

General

M 2a

  

Widened

Yes

0b + 6-mm lacunar infarction

–c

III-6

F

(1) MRI

20

General, T

M

++ (L > R)

Advanced atrophy

Widened

Yes

0b

+

  

(1) CT

26

General P, T

M 3a

 

Advanced atrophy

Widened P

Yes

0b

++

IV-16

F

(1) CT

1

Slight T

Slight M

No

 

Widened

Yes

0b

–c

  

(1) MRI

4

T, P

M P 1a

  

Widened P

Yes

0b

++

IV-9

M

(2) CT

5, 9

General, T

General

 

Atrophy P

Widened P

L > R

1b

 
  

(2) MRI

10, 10

General, T, F Parietal

General 1a

 

Atrophy P

Widened P

L > R

1b

+++

van Swieten et al. [19]

1

F

(1) MRI

4

Mild FT

N/R

N/R

N/R

N/R

L > R

N/R

N/R

2

M

(1) MRI

5

Mild FT

N/R

N/R

N/R

N/R

L > R

N/R

N/R

Passant et al. [42]

III:1

F

(2) MRI

1–4

T

M and A

Atrophy

N/R

N/R

Yes

N/R

N/R

III:2

M

(2) MRI

1–4

T

M and A

Atrophy

N/R

N/R

Yes

N/R

N/R

III:3

M

(2) MRI

1–4

T

M and A

Atrophy

N/R

N/R

Yes

N/R

N/R

III:4

M

(2) MRI

1

T

M and A

Atrophy

N/R

N/R

Yes

N/R

N/R

Lindquist et al. [4]

III/1

F

(1) CT

N/R

Central

N/R

N/R

N/R

N/R

N/R

N/R

N/R

III/3

F

(1) CT

N/R

T

N/R

N/R

N/R

N/R

Yes

N/R

N/R

IV/2

F

(1) MRI

N/R

T

Superficial M

N/R

N/R

N/R

N/R

N/R

N/R

Ikeuchi et al. [43]

P3367-1

M

(1) MRI

N/R

T

M only

Atrophy

Atrophy

N/R

Yes

N/R

N/R

P3367-2

M

(1) MRI

N/R

T

M

N/R

N/R

N/R

Yes

N/R

N/R

P3367-3

F

(1) MRI

N/R

T

M

N/R

N/R

N/R

Yes

N/R

N/R

P3048-1

F

(1) MRI

15

T

M

N/R

N/R

N/R

Yes

N/R

N/R

P3048-2

F

(1) MRI

N/R

T

M

N/R

N/R

N/R

Yes

N/R

N/R

P4550-1

F

(1) MRI

9

T

M

N/R

N/R

N/R

Yes

N/R

N/R

Hirschbichler et al. [3]

1

F

(1) MRI

0–1

Normal

N/R

Asymmetric

N/R

N/R

Hippocampal asymmetry

N/R

N/R

Reed et al. [10]

IV-2

M

(1) MRI

0

Normal

N/R

N/R

N/R

N/R

N/R

N/R

N/R

Komatsu et al. [44]

1

M

(1) MRI

1

Mild FT

N/R

Atrophy

N/R

N/R

N/R

N/R

N/R

Tolboom et al. [12]

1

M

(1) MRI

7

Pronounced T

M and A

Atrophy

N/R

N/R

Yes

N/R

N/R

2

F

(1) MRI

N/R

T

M

Atrophy

N/R

N/R

N/R

N/R

N/R

Ishida et al. [6]

1

M

(1) MRI

N/R

FT

N/R

N/R

N/R

N/R

N/R

N/R

N/R

  

(1) CT

N/R

T

N/R

N/R

N/R

N/R

Yes

N/R

N/R

Wood et al. [17]

1

F

MRI

12

T

N/R

N/R

N/R

N/R

R > L

N/R

N/R

2

F

MRI (>1)

13

T, P

N/R

N/R

N/R

N/R

R > L

N/R

N/R

  1. DD Disease duration at examination, P Progressive, T Temporal, M Medial, A Anterior/ventral, FT Frontotemporal, MRI Magnetic resonance imaging, CT Computed tomography, N/R Not reported
  2. aMedial temporal atrophy assessed with Scheltens scale (0–4)
  3. bAssessed with Fazekas scale (0–3)
  4. cReduced quality due to thick slices or artefacts