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Table 2 Radiological findings in carriers of MAPT R406W

From: Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

  ID Sex Modality (n) DD, years Atrophy pattern Temporal lobe atrophy Hippocampus Parahippocampal gyrus Collateral sulcus Symmetry Vascular pathology Quality
Present study III-1 F (1) CT 2 T M 2a     L > R 0b c
III-3 F (1) CT 28 General 2a   Advanced atrophy   Yes 2b c
III-5 M (1) CT 6 General M 2a    Widened Yes 0b + 6-mm lacunar infarction c
III-6 F (1) MRI 20 General, T M ++ (L > R) Advanced atrophy Widened Yes 0b +
   (1) CT 26 General P, T M 3a   Advanced atrophy Widened P Yes 0b ++
IV-16 F (1) CT 1 Slight T Slight M No   Widened Yes 0b c
   (1) MRI 4 T, P M P 1a    Widened P Yes 0b ++
IV-9 M (2) CT 5, 9 General, T General   Atrophy P Widened P L > R 1b  
   (2) MRI 10, 10 General, T, F Parietal General 1a   Atrophy P Widened P L > R 1b +++
van Swieten et al. [19] 1 F (1) MRI 4 Mild FT N/R N/R N/R N/R L > R N/R N/R
2 M (1) MRI 5 Mild FT N/R N/R N/R N/R L > R N/R N/R
Passant et al. [42] III:1 F (2) MRI 1–4 T M and A Atrophy N/R N/R Yes N/R N/R
III:2 M (2) MRI 1–4 T M and A Atrophy N/R N/R Yes N/R N/R
III:3 M (2) MRI 1–4 T M and A Atrophy N/R N/R Yes N/R N/R
III:4 M (2) MRI 1 T M and A Atrophy N/R N/R Yes N/R N/R
Lindquist et al. [4] III/1 F (1) CT N/R Central N/R N/R N/R N/R N/R N/R N/R
III/3 F (1) CT N/R T N/R N/R N/R N/R Yes N/R N/R
IV/2 F (1) MRI N/R T Superficial M N/R N/R N/R N/R N/R N/R
Ikeuchi et al. [43] P3367-1 M (1) MRI N/R T M only Atrophy Atrophy N/R Yes N/R N/R
P3367-2 M (1) MRI N/R T M N/R N/R N/R Yes N/R N/R
P3367-3 F (1) MRI N/R T M N/R N/R N/R Yes N/R N/R
P3048-1 F (1) MRI 15 T M N/R N/R N/R Yes N/R N/R
P3048-2 F (1) MRI N/R T M N/R N/R N/R Yes N/R N/R
P4550-1 F (1) MRI 9 T M N/R N/R N/R Yes N/R N/R
Hirschbichler et al. [3] 1 F (1) MRI 0–1 Normal N/R Asymmetric N/R N/R Hippocampal asymmetry N/R N/R
Reed et al. [10] IV-2 M (1) MRI 0 Normal N/R N/R N/R N/R N/R N/R N/R
Komatsu et al. [44] 1 M (1) MRI 1 Mild FT N/R Atrophy N/R N/R N/R N/R N/R
Tolboom et al. [12] 1 M (1) MRI 7 Pronounced T M and A Atrophy N/R N/R Yes N/R N/R
2 F (1) MRI N/R T M Atrophy N/R N/R N/R N/R N/R
Ishida et al. [6] 1 M (1) MRI N/R FT N/R N/R N/R N/R N/R N/R N/R
   (1) CT N/R T N/R N/R N/R N/R Yes N/R N/R
Wood et al. [17] 1 F MRI 12 T N/R N/R N/R N/R R > L N/R N/R
2 F MRI (>1) 13 T, P N/R N/R N/R N/R R > L N/R N/R
  1. DD Disease duration at examination, P Progressive, T Temporal, M Medial, A Anterior/ventral, FT Frontotemporal, MRI Magnetic resonance imaging, CT Computed tomography, N/R Not reported
  2. aMedial temporal atrophy assessed with Scheltens scale (0–4)
  3. bAssessed with Fazekas scale (0–3)
  4. cReduced quality due to thick slices or artefacts