Fig. 2

Radiological progression of MAPT R406W-related neurodegeneration. Longitudinal radiological examinations showed increasing ventromedial temporal lobe atrophy with widening of the collateral sulcus (arrowheads) as a characteristic and early sign. Hippocampal atrophy was also seen but was only relatively mild to moderate or became obvious only later in the disease course. DD Duration of disease at examination