Fig. 7

Voxel-based statistical parametric mapping. a Statistical parametric maps at two different levels in the brains of mice at 8 months of age. On these images, for each of the seven metrics (mean diffusivity [MD], axial diffusivity [AD], radial diffusivity [RD], mean kurtosis [MK], axial kurtosis [AK], radial kurtosis [RK] and fractional anisotropy [FA]), the voxels with a decreased value in APP/PS1 mice compared with wild-type (WT) mice are shown in blue, and the voxels with an increased value in APP/PS1 mice compared with WT mice are shown in red. Only voxels with a false discovery rate-corrected p > 0.05 are shown. b Close-up of the FA statistical parametric map showing reduced FA in APP/PS1 mice in the septal nuclei at 8 months of age (blue voxels). c Voxel-based correlation values between the percent optical density (%O.D.) anti-amyloid-β (clone 4G8) antibody (4G8), myelin basic protein (MBP), glial fibrillary acidic protein (GFAP) and ionised calcium-binding adapter molecule 1 (IBA1) and the diffusion tensor metrics (DT), the diffusion kurtosis metrics (DK), and the DT and DK metrics (DT/DK)