Fig. 4

Linear discriminant analysis and least absolute shrinkage and selection operator (LASSO) analysis of the motor cortex. a The frequency distribution histograms of the misclassification error (MCE) of the motor cortex are shown (percentage of animals which were attributed the wrong genotype). The MCE is calculated at 2, 4, 6 and 8 months of age when using only the diffusion tensor (DT) metrics (top row), the diffusion kurtosis (DK) metrics (middle row) or a combination of the DT and DK metrics (bottom row). The red lines indicate the average MCE. b LASSO analysis was done to determine which of the DTI or DKI metrics contribute the most to a correct classification of the genotype. The heat map shows all 100 iterations of the LASSO analysis for all metrics, where green indicates that the metric was used and red indicates that the metric was not used. On the right, we show the percentage of times that the metric contributed to a correct genotype classification in all of these 100 iterations (percent prevalence)