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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Diffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-β-induced pathology

Fig. 3

Region of interest (ROI)-based DKI analysis. The most interesting differences in diffusion tensor and diffusion kurtosis metrics of several grey and white matter ROIs. We show only data from the longitudinal cohort of wild-type WT (blue bars) and APP/PS1 mice (red bars) at 2, 4, 6 and 8 months of age. Shown are the mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD); the mean kurtosis (MK), axial kurtosis (AK) and radial kurtosis (RK); and the fractional anisotropy (FA). Significant differences between WT and APP/PS1 mice at any given time point are shown in black; genotype effect is indicated by green lines; age effect is indicated by orange lines; and interaction between age and genotype is indicated by blue lines. *p < 0.05, **p < 0.01 and ***p < 0.001

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