Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline

Table 3 Cognitive performance and decline, by amyloid-β/white matter hyperintensities groups

		Aβ − WMH−	Aβ − WMH+	Aβ + WMH−	Aβ + WMH+
MMSE	No. of subjects	140	39	62	27
	Baseline	27.79 (27.39, 28.19)	27.52 (26.83, 28.21)	27.20 (26.62, 27.78)	27.40 (26.54, 28.25)
	Slope	−0.01 (−0.15, 0.12)	−0.29 (−0.55, −0.02)	−0.22 (−0.44, −0.01)	−0.31 (−0.62, 0.00)
Memory delayed recall z-score	No. of subjects	133	37	58	27
	Baseline	−0.48 (−0.72, −0.24)^b,c,d	−1.04 (−1.48, −0.61)^e	−1.04 (−1.41, −0.68)^A	−1.33 (−1.86, −0.80)^e
	Slope	0.05 (−0.03, 0.13)	0.02 (−0.12, 0.17)	0.02 (−0.11, 0.14)	−0.07 (−0.24, 0.09)
Executive functioning z-score	No. of subjects	130	37	60	24
	Baseline	−0.48 (−0.76, −0.21)	−0.41 (−0.92, 0.09)	−0.78 (−1.18, −0.37)	−1.12 (−1.73, −0.50)
	Slope	0.06 (−0.02, 0.13)	−0.00 (−0.15, 0.15)	−0.03 (−0.16, 0.10)	−0.04 (−0.23, 0.15)

Abbreviations: Aβ Amyloid-β, MMSE Mini Mental State Examination, WMH White matter hyperintensities
Results are mean (95% CI). Bold slope estimates = p < 0.05. All analyses were adjusted for study. The analyses of MMSE scores were also corrected for demographics and baseline diagnosis
^a p < 0.05 compared to Aβ - WMH-
^b p < 0.05 compared to Aβ - WMH+
^c p < 0.05 compared to Aβ + WMH-
^d p < 0.05 compared to Aβ + WMH+

ISSN: 1758-9193