Univariate HR (95% Cl) | Multivariate | ||
---|---|---|---|
Model 1 HR (95% Cl) | Model 2 HR (95% Cl) | ||
Age | 0.999 (0.976–1.022) | 0.996 (0.970–1.023) | 0.998 (0.972–1.025) |
Female | 1.266 (0.906–1.770) | 1.152 (0.797–1.665) | 1.162 (0.8031–1.682) |
Education | 0.961 (0.907–1.019) | 0.954 (0.900–1.011) | 0.961 (0.906–1.020) |
APOE ε4 carrier | 1.290 (0.896–1.858) | 0.996 (0.674–1.470) | 1.031 (0.700–1.520) |
Cognition | |||
MMSE | 0.821 (0.748–0.901)b | NI | NI |
CDR SB | 1.593 (1.347–1.883)b | 1.526 (1.276–1.824)b | 1.531 (1.279–1.832)b |
ADAS-cog 11 | 1.118 (1.080–1.157)b | 1.101 (1.061–1.144)b | 1.104 (1.063–1.147)b |
CSF markers | |||
CSF t-tau* | 1.003 (1.000–1.006)a | NI | NI |
CSF p-tau** | 1.012 (1.006–1.019)b | 1.006 (1.000–1.013) | 1.006 (1.000–1.013) |
MRI | |||
MTA | 1.682 (1.203–2.352)a | 1.424 (0.997–2.034)a | NI |
PA | 2.244 (1.497–3.364)b | 1.895 (1.239–2.897)b | NI |
Atrophy pattern | |||
No atrophy | Reference | NI | Reference |
MTA only | 2.998 (1.443–6.227)a | NI | 3.178 (1.520–6.645)b |
PA only | 3.126 (1.666–5.864)b | NI | 3.209 (1.693–6.080)b |
Both MTA and PA | 3.814 (2.045–7.110)b | NI | 3.598 (1.909–6.783)b |