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Table 2 Semiquantitative analysis of competition autoradiography using 11C-THK5351, 11C-PBB3, 18F-T807, and unlabeled THK5351, PBB3, and T807

From: Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

  + Unlabeled THK5351 (% inhibition) + Unlabeled PBB3 (% inhibition) + Unlabeled T807 (% inhibition)
11C-THK5351
 Frontal cortex −52 ± 15 Experiment not performed −27 ± 10
 Insula −43 ± 14 −27 ± 2
 Temporal cortex −41 ± 15 −29 ± 13
 Basal ganglia −49 ± 17 −42 ± 5
11C-PBB3    
 Frontal cortex −22 ± 5 −53 ± 3 −18 ± 3
 Insula −19 ± 1 −46 ± 2 −14 ± 6
 Temporal cortex −27 ± 9 −50 ± 9 −9 ± 4
 Basal ganglia −21 ± 3 −48 ± 1 −18 ± 4
18F-T807
 Frontal cortex Experiment not performed Experiment not performed −35 ± 10
 Insula −27 ± 8
 Temporal cortex −30 ± 15
 Basal ganglia −26 ± 4
  1. This table shows the extent of inhibition of binding (as a percentage) by unlabeled T807 of 11C-THK5351 by unlabeled THK5351 and T807; of 11C-PBB3 by unlabeled THK5351, PBB3, and T807; and of 11C-T807. The values presented are mean ± SD of values from three Alzheimer’s disease brain samples