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Fig. 8 | Alzheimer's Research & Therapy

Fig. 8

From: Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

Fig. 8

3H-THK5351 autoradiography competition with unlabeled THK5351, T807, and deprenyl. 3H-THK5351 comparisons in large frozen postmortem brain sections from a patient with Alzheimer’s disease (AD1). a Total binding (1.5 nM of 3H-THK5351). b Competition with 10 μM unlabeled THK5351. c Competition with 10 μM unlabeled T807. d Competition with 10 μM unlabeled deprenyl. e Competition with 10 μM unlabeled THK5351 + 10 μM unlabeled deprenyl. f Competition with 10 μM unlabeled T807 + 10 μM unlabeled deprenyl. The percentage inhibition of binding by the unlabeled compounds in AD1 tissue for the various regions is marked

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Alzheimer's Research & Therapy

ISSN: 1758-9193