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Table 3 Linear regression analysis of CSF selenium species levels versus log-transformed values of biomarkers of Alzheimer’s disease pathology (β-amyloid and p-tau as dependent variables) in the 56 MCI study participants at baseline

From: A selenium species in cerebrospinal fluid predicts conversion to Alzheimer’s dementia in persons with mild cognitive impairment

Se species

(N)

Crude

Adjusted

β

95% CI

β

95% CI

β-amyloid

 Total Se

(56)

0.03

(–0.09 to 0.15)

0.02

(–0.11 to 0.15)

 Inorganic Se

(56)

–0.27

(–0.66 to 0.11)

–0.26

(–0.66 to 0.15)

  Se(IV)

(53)

–0.12

(–0.75 to 0.51)

–0.09

(–0.78 to 0.60)

  Se(VI)

(50)

–0.74

(–1.63 to 0.16)

–0.81

(–1.74 to 0.13)

 Organic Se

(56)

0.16

(0.02 to 0.30)

0.18

(0.01 to 0.34)

  Se-SelenoP

(56)

0.15

(–0.00 to 0.31)

0.17

(–0.02 to 0.36)

  Se-Met

(54)

1.87

(0.52 to 3.23)

2.30

(0.81 to 3.79)

  Se-Cys

(12)

1.01

(–3.17 to 5.18)

2.93

(–1.33 to 7.18)

  Se-GPX

(24)

0.41

(–1.50 to 2.33)

0.52

(–1.60 to 2.64)

 Se-HSA

(25)

–0.00

(–0.22 to 0.21)

0.02

(–0.22 to 0.25)

 Unknown

(56)

–0.08

(–0.57 to 0.41)

–0.14

(–0.72 to 0.43)

p-tau

 Total Se

(56)

0.06

(–0.08 to 0.19)

0.09

(–0.05 to 0.23)

 Inorganic Se

(56)

–0.02

(–0.45 to 0.41)

–0.09

(–0.53 to 0.35)

  Se(IV)

(53)

–0.31

(–0.98 to 0.37)

–0.58

(–1.29 to 0.14)

  Se(VI)

(50)

0.33

(–0.62 to 1.28)

0.23

(–0.74 to 1.20)

 Organic Se

(56)

0.02

(–0.14 to 0.18)

0.10

(–0.08 to 0.28)

  Se-SelenoP

(56)

0.03

(–0.15 to 0.20)

0.13

(–0.08 to 0.33)

  Se-Met

(54)

–0.26

(–1.83 to 1.31)

0.10

(–1.63 to 1.82)

  Se-Cys

(12)

–0.69

(–5.45 to 4.60)

–1.59

(–8.23 to 5.05)

  Se-GPX

(24)

–0.09

(–2.52 to 2.34)

–0.45

(–3.11 to 2.21)

 Se-HSA

(25)

0.05

(–0.20 to 0.30)

0.04

(–0.22 to 0.31)

 Unknown

(56)

0.61

(0.10 to 1.12)

0.75

(0.17 to 1.33)

  1. Adjusted estimates are from a multivariable model including sex, age, education, and duration of sample storage as potential confounders. Values below the limit of detection were excluded from the analysis
  2. β-amyloid1–42, CI confidence interval, CSF cerebrospinal fluid, MCI mild cognitive impairment, p-tau phosphorylated tau protein, Se selenium, Se(IV) selenite, Se(VI) selenate, Se-SelenoP selenoprotein P-bound Se, Se-Met selenomethionine-bound Se, Se-Cys selenocysteine-bound Se, Se-GPX glutathione-peroxidase-bound Se, Se-HSA human serum albumin selenium-bound Se