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Table 3 Results of the generalized estimating equation analyzing the effect of 2-year MMSE changes in patients with AD

From: The clinical significance of plasma clusterin and Aβ in the longitudinal follow-up of patients with Alzheimer’s disease

  β SE 95% CI P value
Gender
 Male −0.32 0.83 (−1.95, 1.32) 0.71
 Female Referent    
Clusterin level
 High −2.09 0.81 (−3.67, −0.51) 0.01
 Medium −0.87 0.71 (−2.27, 0.53) 0.22
 Low Referent    
ApoE4 carrier
 Positive −2.75 0.69 (−4.11, −1.39) 0.00
 Negative Referent    
Age 0.03 0.08 (−0.12, 0.17) 0.74
Education years 0.13 0.09 (−0.04, 0.30) 0.15
Time −0.91 0.21 (−1.33, −0.49) 0.00
  1. Adjusted for age, education years, gender, time, and ApoE4 carrier
  2. Interaction in group*ApoE4 carrier: p value = 0.93 and group*time: p value = 0.21
  3. AD Alzheimer’s disease, ApoE apolipoprotein E, CI confidence interval, MMSE Mini-Mental State Examination, SE standard error