Fig. 2

Plasma biomarkers associated with longitudinal changes in NPI-agitation/aggression scores based on the differences in ApoE4 carrier status. a Compared with the Aβ1–42/Aβ1–40 ratios in the low tertile, those in the high tertile were associated with a significant increase in NPI-agitation/aggression scores in ApoE4-positive carriers based on a GEE analysis adjusted for age, gender, and years of education (p = 0.02). b There was no significant difference between groups for NPI-agitation/aggression scores in ApoE4-negative carriers based on a GEE analysis adjusted for age, gender, and years of education. Data are presented as the mean ± standard error. Aβ amyloid beta peptide, AD Alzheimer’s disease, NPI Neuropsychiatric Inventory