Fig. 1

Plasma biomarkers associated with longitudinal changes in MMSE scores. Patients in the high tertile of plasma clusterin levels had significantly lower Mini-Mental State Examination (MMSE) scores compared with those in the low tertile based on a GEE analysis adjusted for age, gender, years of education, and ApoE4 carrier status (p = 0.01). There was no significant interaction between time and the tertile of plasma clusterin (p = 0.10). Data are presented as the mean ± standard error. AD Alzheimer’s disease