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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

Fig. 6

Increased amyloid-β (Aβ)4–x levels in homozygous 5XFAD mice a. Quantification of extracellular 029-2-positive plaque load in cortex, subiculum, and thalamus in heterozygous and homozygous 9-month-old 5XFAD mice. b Quantification of sodium dodecyl sulfate-soluble Aβ4–40 levels in brains of heterozygous and homozygous 5-month-old 5XFAD mice revealed a significant gene dose-dependent increase. ***p < 0.001; *p < 0.05. ELISA Enzyme-linked immunosorbent assay, FAD Familial Alzheimer’s disease

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