PKR involvement in Alzheimer’s disease

Table 1 Published reports on PKR and Alzheimer’s disease

Report	Sample	Results
Chang et al. 2002 [45]	Brain	pPKR neuronal accumulation
Peel et al. 2003 [39]	Brain	pPKR neuronal accumulation
Onuki et al. 2004 [32]	Brain	pPKR neuronal accumulation
Paccalin et al. 2006 [71]	PBL	pPKR increased level
Page et al. 2006 [40]	Brain	pPKR increased concentration
Bullido et al. 2008 [74]	DNA	PKR gene association
Damjanac et al. 2009 [72]	PBL	PKR-dependent increases in P53, Redd1
Couturier et al. 2010 [35]	PBL	PKR control of inflammation
Bose et al. 2011 [47]	Brain	Co-localization of pPKR and ptau
Paquet et al. 2012 [69]	Brain	Increased levels of PKR activator PACT
Mouton-Liger et al. 2012 [76]	CSF	Increased levels of PKR and pPKR
Badia et al. 2013 [73]	PBL	Increased levels of PKR RNA in ApoE4 patients
Dumurgier et al. 2013 [77]	CSF	CSF pPKR predicts cognitive decline
Paquet et al. 2015 [79]	Brain	Aβ vaccine reduces pPKR load
Taga et al. 2017 [70]	Brain	Correlations cognitive scores and pPKR load

Non-exhaustive list of published studies that assessed the levels of PKR signals in human AD samples, including brain, peripheral blood lymphocytes (PBL), and cerebrospinal fluid (CSF)