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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: ERβ and ApoE isoforms interact to regulate BDNF–5-HT2A signaling and synaptic function in the female brain

Fig. 2

Pre- and postsynaptic proteins are differentially modulated by apolipoprotein E (ApoE) isoforms. Expression levels of (a) presynaptic proteins synaptophysin and synaptobrevin2, and (b) postsynaptic proteins PSD95 and SHANK3 were examined in the cortices of 6-month-old human ApoE2, ApoE3, and ApoE4 gene-targeted replacement female mice. The integrated density value of the bands in Western blots was determined using densitometry, and data were normalized to an internal loading control (β-tubulin) and to the ApoE2 group. Data are shown as mean ± SD (n = 5). *p < 0.05, **p < 0.01, ***p < 0.001 by one-way analysis of variance with Tukey’s post hoc test

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