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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: ERβ and ApoE isoforms interact to regulate BDNF–5-HT2A signaling and synaptic function in the female brain

Fig. 1

Brain-derived neurotrophic factor (BDNF) and 5-hydroxytryptamine 2A (5-HT2A) expression levels are modulated by apolipoprotein E (ApoE) in an isoform-dependent manner. Expression levels of (a) BDNF and tropomyosin receptor kinase B (TrkB) and (b) 5-HT1A and 5-HT2A were examined in the cortices of 6-month-old human ApoE2, ApoE3, and ApoE4 gene-targeted replacement female mice. The integrated density value of the bands in Western blots was determined using densitometry, and data were normalized to an internal loading control (β-tubulin) and to the ApoE2 group. Data are shown as mean ± SD (n = 5). *p < 0.05, **p < 0.01 by one-way analysis of variance with Tukey’s post hoc test

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