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Table 1 Twenty most discriminating metabolites from orthogonal projections to latent structures discriminant analysis (sorted by absolute value of pcorr1 axis; variation related to variable magnitude)

From: Metabolic status of CSF distinguishes rats with tauopathy from controls

Cerebrospinal fluid

Plasma

Brain tissue

Name

p1

pcorr1

Fold change

p Value (α = 5.21E-04)a

Name

p1

pcorr1

Fold change

p Value (α = 3.07E-04)a

Name

p1

pcorr1

Fold change

p Value (α = 2.06E-04)a

Tr

−0.91

−0.95

0.64

1.68E-07

Glutamine

0.97

0.93

1.19

1.37E-03

NaMN

2.15

0.95

1.52

4.44E-03

Citrate_isocitrate

−1.06

−0.93

0.52

8.71E-08

Proline

1.39

0.91

1.43

1.74E-03

CDP

4.47

0.95

6.36

2.94E-02

Carnitine

−0.78

−0.9

0.76

2.90E-05

Spermine

1.38

0.9

1.45

6.81E-04

ATP

4.12

0.93

6.55

4.47E-02

Myo-inositol

0.77

0.86

1.38

1.29E-04

Creatinine

1.5

0.89

1.67

3.33E-06

ADP

3.24

0.92

2.53

7.97E-02

Deoxyuridine

−0.6

−0.82

0.83

2.66E-04

DHA

−1.59

−0.89

0.7

4.67E-03

dGDP

3.22

0.92

2.27

6.39E-02

Cytosine

−0.61

−0.8

0.79

6.89E-04

Citrulline

1.43

0.87

1.49

1.08E-02

3PG

3.36

0.91

2.75

9.99E-02

S-ArMet

0.57

0.75

1.23

3.59E-03

C12

−1.75

−0.84

0.6

8.70E-02

Xanthine

−3.34

−0.9

0.34

2.63E-02

Creatinine

0.5

0.75

1.12

1.40E-03

C14:1OH

−1.58

−0.82

0.71

6.03E-02

UDP

4.03

0.9

5.1

5.52E-02

Ribose

0.45

0.71

1.15

9.23E-04

mHis_NmHis

−1.33

−0.82

0.73

2.60E-03

Hx

−3.38

−0.9

0.34

2.22E-01

mHis_NmHis

−0.63

−0.7

0.68

8.27E-03

NAcGlcnh2_NAcGalnh2_NAcManh2

1.23

0.82

1.42

2.80E-03

IDP

3.08

0.89

2.18

1.15E-01

Allantoin

−0.6

−0.69

0.82

2.91E-03

Succ_mma

1.44

0.81

1.32

1.24E-02

Inosine

−3.49

−0.89

0.28

1.98E-01

hCar

0.47

0.69

1.22

2.25E-02

Arabitol_ribitol

1.69

0.8

1.55

8.61E-02

dimGly_nh2isobut

−2.52

−0.88

0.51

1.84E-01

Glucose

0.46

0.68

1.2

2.19E-03

Trigonelline

1.85

0.79

1.58

4.00E-02

Uracil

−2.9

−0.88

0.47

2.44E-01

Succ_mma

0.36

0.66

1.08

4.89E-03

C14

−1.6

−0.78

0.76

1.48E-01

rib5P

−3.16

−0.86

0.34

2.62E-01

Aconitate

−0.54

−0.64

0.78

1.42E-02

oPro_pipec

0.82

0.78

1.15

7.67E-03

PCr

4.38

0.86

4.81

2.69E-01

Uridine

0.45

0.63

1.19

4.74E-03

C14

−1.53

−0.76

0.68

1.18E-01

Niacin

−1.93

−0.85

0.63

1.63E-01

Valine

−0.4

−0.59

0.83

4.95E-02

C14:1

−1.52

−0.76

0.58

8.49E-02

GuaBut

2.35

0.85

1.88

2.59E-01

Phenyl acetate

0.8

0.59

2.05

3.72E-02

C18:1

−1.47

−0.75

0.66

1.36E-01

acMet

−2.78

−0.85

0.54

3.10E-01

Fructose

0.4

0.59

1.2

1.69E-02

C16

−1.62

−0.75

0.72

1.26E-01

NADP

3.67

0.84

2.27

1.94E-02

C5

−0.5

−0.57

0.69

2.71E-02

C16OH

−1.4

−0.74

0.73

1.49E-01

Tr

−2.3

−0.84

0.6

2.04E-02

  1. Abbreviations: 3PG Glycerate 3-phosphate, acMet N-acetylmethionine, C12 Dodecanoylcarnitine, C14 Tetradecanoylcarnitine, C14:1 Tetradecenoylcarnitine, C14:1OH Hydroxytetradecenoylcarnitine, C16 Hexadecanoylcarnitine, C16:1OH Hydroxyhexadecenoylcarnitine, C16OH Hydroxyhexadecanoylcarnitine, C18:1 Octadecenoylcarnitine, C5 Valerylcarnitine, CDP Cytidine 5′-diphosphate, dGDP Deoxyguanosine 5′-diphosphate, DHA Docosahexaenoic acid, dimGly_nh2isobut Dimethylglycine/2-aminoisobutyric acid, GuaBut Guanidinobutanoate, hCar Homocarnosine, Hx Hypoxanthine, IDP Inosine 5′-diphosphate, mHis_NmHis 3-Methylhistidine/N-methylhistidine, NAcGlcnh2_NAcGalnh2_NAcManh2 N-acetylglucosamine/N-acetylgalactosamine/N-acetylmannosamine, NADP Nicotinamide adenine dinucleotide phosphate, NaMN Nicotinamide mononucleotide, oPro_pipec 5-Oxoproline/ pipecolate, PCr Phosphocreatine, rib5P_xyl5P Ribose 5-phosphate/xylulose 5-phosphate, S-ArMet S-adenosylmethionine, Succ_mma Succinate/methylmalonate, Tr Thymidine, UDP Uridine 5′-diphosphate
  2. p Values and fold changes for metabolites are shown
  3. aCorrected α value (after Bonferroni correction)
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Alzheimer's Research & Therapy

ISSN: 1758-9193