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Table 1 Twenty most discriminating metabolites from orthogonal projections to latent structures discriminant analysis (sorted by absolute value of pcorr1 axis; variation related to variable magnitude)

From: Metabolic status of CSF distinguishes rats with tauopathy from controls

Cerebrospinal fluid Plasma Brain tissue
Name p1 pcorr1 Fold change p Value (α = 5.21E-04)a Name p1 pcorr1 Fold change p Value (α = 3.07E-04)a Name p1 pcorr1 Fold change p Value (α = 2.06E-04)a
Tr −0.91 −0.95 0.64 1.68E-07 Glutamine 0.97 0.93 1.19 1.37E-03 NaMN 2.15 0.95 1.52 4.44E-03
Citrate_isocitrate −1.06 −0.93 0.52 8.71E-08 Proline 1.39 0.91 1.43 1.74E-03 CDP 4.47 0.95 6.36 2.94E-02
Carnitine −0.78 −0.9 0.76 2.90E-05 Spermine 1.38 0.9 1.45 6.81E-04 ATP 4.12 0.93 6.55 4.47E-02
Myo-inositol 0.77 0.86 1.38 1.29E-04 Creatinine 1.5 0.89 1.67 3.33E-06 ADP 3.24 0.92 2.53 7.97E-02
Deoxyuridine −0.6 −0.82 0.83 2.66E-04 DHA −1.59 −0.89 0.7 4.67E-03 dGDP 3.22 0.92 2.27 6.39E-02
Cytosine −0.61 −0.8 0.79 6.89E-04 Citrulline 1.43 0.87 1.49 1.08E-02 3PG 3.36 0.91 2.75 9.99E-02
S-ArMet 0.57 0.75 1.23 3.59E-03 C12 −1.75 −0.84 0.6 8.70E-02 Xanthine −3.34 −0.9 0.34 2.63E-02
Creatinine 0.5 0.75 1.12 1.40E-03 C14:1OH −1.58 −0.82 0.71 6.03E-02 UDP 4.03 0.9 5.1 5.52E-02
Ribose 0.45 0.71 1.15 9.23E-04 mHis_NmHis −1.33 −0.82 0.73 2.60E-03 Hx −3.38 −0.9 0.34 2.22E-01
mHis_NmHis −0.63 −0.7 0.68 8.27E-03 NAcGlcnh2_NAcGalnh2_NAcManh2 1.23 0.82 1.42 2.80E-03 IDP 3.08 0.89 2.18 1.15E-01
Allantoin −0.6 −0.69 0.82 2.91E-03 Succ_mma 1.44 0.81 1.32 1.24E-02 Inosine −3.49 −0.89 0.28 1.98E-01
hCar 0.47 0.69 1.22 2.25E-02 Arabitol_ribitol 1.69 0.8 1.55 8.61E-02 dimGly_nh2isobut −2.52 −0.88 0.51 1.84E-01
Glucose 0.46 0.68 1.2 2.19E-03 Trigonelline 1.85 0.79 1.58 4.00E-02 Uracil −2.9 −0.88 0.47 2.44E-01
Succ_mma 0.36 0.66 1.08 4.89E-03 C14 −1.6 −0.78 0.76 1.48E-01 rib5P −3.16 −0.86 0.34 2.62E-01
Aconitate −0.54 −0.64 0.78 1.42E-02 oPro_pipec 0.82 0.78 1.15 7.67E-03 PCr 4.38 0.86 4.81 2.69E-01
Uridine 0.45 0.63 1.19 4.74E-03 C14 −1.53 −0.76 0.68 1.18E-01 Niacin −1.93 −0.85 0.63 1.63E-01
Valine −0.4 −0.59 0.83 4.95E-02 C14:1 −1.52 −0.76 0.58 8.49E-02 GuaBut 2.35 0.85 1.88 2.59E-01
Phenyl acetate 0.8 0.59 2.05 3.72E-02 C18:1 −1.47 −0.75 0.66 1.36E-01 acMet −2.78 −0.85 0.54 3.10E-01
Fructose 0.4 0.59 1.2 1.69E-02 C16 −1.62 −0.75 0.72 1.26E-01 NADP 3.67 0.84 2.27 1.94E-02
C5 −0.5 −0.57 0.69 2.71E-02 C16OH −1.4 −0.74 0.73 1.49E-01 Tr −2.3 −0.84 0.6 2.04E-02
  1. Abbreviations: 3PG Glycerate 3-phosphate, acMet N-acetylmethionine, C12 Dodecanoylcarnitine, C14 Tetradecanoylcarnitine, C14:1 Tetradecenoylcarnitine, C14:1OH Hydroxytetradecenoylcarnitine, C16 Hexadecanoylcarnitine, C16:1OH Hydroxyhexadecenoylcarnitine, C16OH Hydroxyhexadecanoylcarnitine, C18:1 Octadecenoylcarnitine, C5 Valerylcarnitine, CDP Cytidine 5′-diphosphate, dGDP Deoxyguanosine 5′-diphosphate, DHA Docosahexaenoic acid, dimGly_nh2isobut Dimethylglycine/2-aminoisobutyric acid, GuaBut Guanidinobutanoate, hCar Homocarnosine, Hx Hypoxanthine, IDP Inosine 5′-diphosphate, mHis_NmHis 3-Methylhistidine/N-methylhistidine, NAcGlcnh2_NAcGalnh2_NAcManh2 N-acetylglucosamine/N-acetylgalactosamine/N-acetylmannosamine, NADP Nicotinamide adenine dinucleotide phosphate, NaMN Nicotinamide mononucleotide, oPro_pipec 5-Oxoproline/ pipecolate, PCr Phosphocreatine, rib5P_xyl5P Ribose 5-phosphate/xylulose 5-phosphate, S-ArMet S-adenosylmethionine, Succ_mma Succinate/methylmalonate, Tr Thymidine, UDP Uridine 5′-diphosphate
  2. p Values and fold changes for metabolites are shown
  3. aCorrected α value (after Bonferroni correction)