Personalized predictive modeling for patients with Alzheimer’s disease using an extension of Sullivan’s life table model

Table 2 Symptom severity for Alzheimer’s disease subtypes on the 35 most salient covariates and 5 salient summary measures

				Subtype
j	Domain	Name	Description	1	2	3	4
Salient covariates
8	1	PP44	Verbal outbursts			H
12	2	Orientation_RC	MMSE: sum of orientation variables	L			H
17	2	SP41B	MMSE: intersecting pentagons				H
18	3	NN01	Patient trouble with chores	L			H
19	3	NN02	Patient trouble handling money	L			H
20	3	NN03	Patient trouble remembering lists	L
21	3	NN04	Patient trouble around house				H
22	3	NN05	Patient trouble around neighborhood	L	L		H
23	3	NN06	Patient trouble recognizing place	L	L		H
24	3	NN07	Patient trouble remembering things	L
25	3	NN08	Patient dwells in the past			H
27	3	NN10	Patient dressing	L			H
28	3	NN11	Patient bladder and bowel control				H
29	3	NN12	Increased rigidity			H
30	3	NN13	Increased egocentricity			H
31	3	NN14	Impairment of regard for feelings of others			H
32	3	NN15	Coarsening of affect			H
33	3	NN16	Impairment of emotional control			H
35	3	NN18	Diminished emotional responsiveness	L
36	3	NN19	Sexual misdemeanor			H
37	3	NN20	Hobbies relinquished	L
40	4	RR01	Needs reminders	L
41	4	RR02	Needs help to remember	L
43	4	RR04	Needs household chores done	L
44	4	RR05	Needs watching when awake	L	L		H
45	4	RR06	Needs to be escorted when outside	L	L		H
46	4	RR07	Needs to be accompanied bathing/eating	L	L		H
47	4	RR08	Needs to be dressed/washed/groomed				H
48	4	RR09	Needs to be taken to toilet				H
51	4	RR12	Needs to wear diaper/catheter				H
53	4	RR15	Equivalent institutional care	L		M	H
61	7	DELUSION	Delusions			H
67	9	EPSXX	Extrapyramidal symptoms				H
73	10	AGITATION	Agitation			H
74	10	SAD	Sadness/depression			H
Total H/L				17	5	11	17
Salient Summary Measures
—	—	QQ01_RC	CDR rating	L	L		H
—	2	SP51_RC	MMSE score	L			H
—	3	NNTOT_RC	BDRS score	L	L	M	H
—	4	RR14	Dependence scale score	L	L	M	H
—	7	PSYCHSX	Psychiatric symptoms			H
Total H/L				4	3	1	4

Abbreviations: BDRS Blessed Dementia Rating Scale, CDR Clinical Dementia Rating, LMH Low, medium, or high severity, MMSE Mini Mental State Examination
j denotes variable number. LMH designations indicate the direction and strength of the symptom severity for the indicated subtypes. LMH designations are provided for covariates with positive Bayesian information criterion statistics in Additional file 1: Table A.2, but only if the corresponding Kullback-Leibler information statistics exceed 0.50. These conditions identified the 35 most salient covariates shown above. The summary measures were processed using conditional maximum likelihood estimation procedures that did not impact the estimated Grade of Measurement scores. In three cases, the conditions for assigning H or L were met, but the effect involved a restricted set of intermediate severity levels, which were coded as M

ISSN: 1758-9193