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Table 2 Symptom severity for Alzheimer’s disease subtypes on the 35 most salient covariates and 5 salient summary measures

From: Personalized predictive modeling for patients with Alzheimer’s disease using an extension of Sullivan’s life table model

    

Subtype

j

Domain

Name

Description

1

2

3

4

Salient covariates

8

1

PP44

Verbal outbursts

  

H

 

12

2

Orientation_RC

MMSE: sum of orientation variables

L

  

H

17

2

SP41B

MMSE: intersecting pentagons

   

H

18

3

NN01

Patient trouble with chores

L

  

H

19

3

NN02

Patient trouble handling money

L

  

H

20

3

NN03

Patient trouble remembering lists

L

   

21

3

NN04

Patient trouble around house

   

H

22

3

NN05

Patient trouble around neighborhood

L

L

 

H

23

3

NN06

Patient trouble recognizing place

L

L

 

H

24

3

NN07

Patient trouble remembering things

L

   

25

3

NN08

Patient dwells in the past

  

H

 

27

3

NN10

Patient dressing

L

  

H

28

3

NN11

Patient bladder and bowel control

   

H

29

3

NN12

Increased rigidity

  

H

 

30

3

NN13

Increased egocentricity

  

H

 

31

3

NN14

Impairment of regard for feelings of others

  

H

 

32

3

NN15

Coarsening of affect

  

H

 

33

3

NN16

Impairment of emotional control

  

H

 

35

3

NN18

Diminished emotional responsiveness

L

   

36

3

NN19

Sexual misdemeanor

  

H

 

37

3

NN20

Hobbies relinquished

L

   

40

4

RR01

Needs reminders

L

   

41

4

RR02

Needs help to remember

L

   

43

4

RR04

Needs household chores done

L

   

44

4

RR05

Needs watching when awake

L

L

 

H

45

4

RR06

Needs to be escorted when outside

L

L

 

H

46

4

RR07

Needs to be accompanied bathing/eating

L

L

 

H

47

4

RR08

Needs to be dressed/washed/groomed

   

H

48

4

RR09

Needs to be taken to toilet

   

H

51

4

RR12

Needs to wear diaper/catheter

   

H

53

4

RR15

Equivalent institutional care

L

 

M

H

61

7

DELUSION

Delusions

  

H

 

67

9

EPSXX

Extrapyramidal symptoms

   

H

73

10

AGITATION

Agitation

  

H

 

74

10

SAD

Sadness/depression

  

H

 

Total H/L

  

17

5

11

17

Salient Summary Measures

QQ01_RC

CDR rating

L

L

 

H

2

SP51_RC

MMSE score

L

  

H

3

NNTOT_RC

BDRS score

L

L

M

H

4

RR14

Dependence scale score

L

L

M

H

7

PSYCHSX

Psychiatric symptoms

  

H

 

Total H/L

  

4

3

1

4

  1. Abbreviations: BDRS Blessed Dementia Rating Scale, CDR Clinical Dementia Rating, LMH Low, medium, or high severity, MMSE Mini Mental State Examination
  2. j denotes variable number. LMH designations indicate the direction and strength of the symptom severity for the indicated subtypes. LMH designations are provided for covariates with positive Bayesian information criterion statistics in Additional file 1: Table A.2, but only if the corresponding Kullback-Leibler information statistics exceed 0.50. These conditions identified the 35 most salient covariates shown above. The summary measures were processed using conditional maximum likelihood estimation procedures that did not impact the estimated Grade of Measurement scores. In three cases, the conditions for assigning H or L were met, but the effect involved a restricted set of intermediate severity levels, which were coded as M