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Table 5 P values showing statistical comparisons of the specificities of the receiver operating characteristic curves for the best one-, two-, three-, and four-predictor combinations at a given sensitivity of 85%

From: Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia

  t-Tau t-Tau, HCV t-Tau, HCV, CDR-sb t-Tau, HCV, CDR-sb, Aβ42/Aβ40
HCV ns 0.03 0.001 0.000
t-Tau   ns 0.01 0.003
t-Tau, HCV    ns ns
t-Tau, HCV, CDR-sb     ns
  1. Data were not corrected for multiple testing
  2. For comparing the values we used a bootstrapping algorithm as implemented in pROC packages (Version 1.8)
  3. All predictor combinations were statistically superior to single predictors, but none of the best three- and four-parameter combination was statistically superior to the two-predictor combination
  4. Aβ40 amyloid-beta1–40, Aβ42 amyloid-beta1–42, CDR-sb Clinical Dementia Rating–sum-of-boxes, HCV hippocampal volume, ns not significant, t-Tau total tau