Predictors
|
AUC
|
Youden index
|
Sensitivity
|
Specificity
|
PPV
|
NPV
|
---|
Single predictors
|
t-Tau
| | | |
0.77
|
1.48
|
0.62
|
0.86
|
0.42
|
0.93
|
HCV
| | | |
0.74
|
1.45
|
0.63
|
0.82
|
0.42
|
0.92
|
CDR-sb
| | | |
0.73
|
1.38
|
0.45
|
0.93
|
0.35
|
0.95
|
CERAD-DR
| | | |
0.72
|
1.39
|
0.64
|
0.75
|
0.40
|
0.89
|
MMSE
| | | |
0.71
|
1.36
|
0.68
|
0.68
|
0.40
|
0.87
|
p-Tau
| | | |
0.69
|
1.41
|
0.81
|
0.61
|
0.50
|
0.86
|
Aβ42
| | | |
0.68
|
1.38
|
0.74
|
0.64
|
0.44
|
0.87
|
Aβ42/Aβ40
| | | |
0.66
|
1.34
|
0.59
|
0.75
|
0.37
|
0.88
|
Aβ40
| | | |
0.55
|
1.15
|
0.76
|
0.39
|
0.34
|
0.80
|
APO E
| | | |
0.50
|
1.05
|
0.41
|
0.64
|
0.26
|
0.47
|
Two-predictor combinations
|
t-Tau
|
HCV
| | |
0.81
|
1.45
|
0.68
|
0.77
|
0.49
|
0.88
|
t-Tau
|
CDR-sb
| | |
0.79
|
1.44
|
0.83
|
0.61
|
0.41
|
0.92
|
t-Tau
|
MMSE
| | |
0.79
|
1.46
|
0.81
|
0.65
|
0.43
|
0.91
|
t-Tau
|
CERAD-DR
| | |
0.78
|
1.43
|
0.62
|
0.81
|
0.52
|
0.87
|
p-Tau
|
HCV
| | |
0.77
|
1.40
|
0.76
|
0.64
|
0.42
|
0.89
|
Three-predictor combinations
|
t-Tau
|
HCV
|
CDR-sb
| |
0.83
|
1.54
|
0.84
|
0.70
|
0.48
|
0.93
|
t-Tau
|
HCV
|
MMSE
| |
0.81
|
1.47
|
0.83
|
0.64
|
0.44
|
0.92
|
t-Tau
|
MMSE
|
CDR-sb
| |
0.81
|
1.47
|
0.76
|
0.70
|
0.46
|
0.90
|
t-Tau
|
CDR-sb
|
CERAD-DR
| |
0.80
|
1.48
|
0.79
|
0.70
|
0.47
|
0.91
|
HCV
|
MMSE
|
Aβ42/Aβ40
| |
0.80
|
1.48
|
0.78
|
0.70
|
0.45
|
0.91
|
Four-predictor combinations
|
t-Tau
|
HCV
|
CDR-sb
|
Aβ42/Aβ40
|
0.82
|
1.55
|
0.89
|
0.67
|
0.47
|
0.95
|
t-Tau
|
p-Tau
|
CDR-sb
|
Aβ42/Aβ40
|
0.82
|
1.49
|
0.78
|
0.71
|
0.47
|
0.91
|
t-Tau
|
HCV
|
p-Tau
|
Aβ42/Aβ40
|
0.82
|
1.49
|
0.85
|
0.64
|
0.42
|
0.93
|
t-Tau
|
HCV
|
CDR-sb
|
CERAD-DR
|
0.81
|
1.57
|
0.80
|
0.76
|
0.52
|
0.92
|
HCV
|
MMSE
|
CDR-sb
|
Aβ42/Aβ40
|
0.81
|
1.51
|
0.86
|
0.65
|
0.46
|
0.93
|
- The predictors are sorted according to the AUC
- All values correspond to mean bootstrap-based cross-validated performance
-
Aβ40 amyloid-beta1–40, Aβ42 amyloid-beta1–42, AD Alzheimer’s disease, AUC area under the curve, CDR-sb Clinical Dementia Rating–sum-of-boxes, CERAD-DR Consortium to Establish a Registry of Dementia–delayed recall, HCV hippocampal volume, MCI cognitive impairment, MMSE Mini-Mental State Examination, NPV negative predictive value, PPV positive predictive value, p-Tau phosphorylated tau, t-Tau total tau