Fig. 2

ROC curves of the best single and two- to four-parameter classifiers, based on 100 replicates of a 0.632 bootstrapping algorithm based on support vector machine classifier. A boxplot of areas under the curves (AUCs) for the different classification engines is shown in the insert. The AUC values of the different classification engines were not significantly different from each other. CDR.SB Clinical Dementia Rating–sum-of-boxes, HIPPO hippocampal volume, ttau total tau, ratio42_40 amyloid-beta_1–42/amyloid-beta_1–42 ratio