Alzheimer's Research & Therapy

Table 3 Summary of regression moderation analyses for left and right hippocampal volume outcomes (n = 526)

From: Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume

	Left hippocampus^a				Right hippocampus^a
Variable	β Coefficient	p Value	95% CI		β Coefficient	p Value	95% CI
Amyloid PET positivity	−77.566	0.092	−167.751	12.619	−104.569	0.021	−192.943	−16.195
Diagnosis	−246.297	<0.0001	−328.569	164.024	−249.308	<0.0001	−333.037	165.578
Sex	−54.713	0.193	−137.229	27.802	−66.609	0.111	−148.498	15.28
A⁺ × diagnosis × sex	−57.528	0.726	−380.114	265.058	−276.81	0.089	−596.41	42.789
A⁺ × diagnosis	−137.015	0.094	−297.34	23.309	−123.397	0.127	−281.968	35.173
A⁺ × sex	90.467	0.259	−66.718	247.652	77.968	0.329	−78.934	234.869
Diagnosis × sex	−61.618	0.454	−223.256	100.021	−135.762	0.097	−296.177	24.654
Age	−26.758	<0.0001	−32.976	20.539	−30.667	<0.0001	−36.752	−24.583
Education	0.312	0.969	−15.337	15.962	−8.534	0.281	−24.0581	6.989
Modified MoCA	34	0.001	13.599	54.4	31.479	0.003	10.901	52.057
APOE ε4 carrier status	−15.354	0.742	−107.004	76.297	−29.992	0.513	−120.083	60.099

Abbreviations: A ⁺ Florbetapir positron emission tomography amyloid positivity, APOE Apolipoprotein E, MoCA Montreal Cognitive Assessment, PET Positron emission tomography
Age, education, and modified MoCA scores were centered at their means. Dichotomous variables were centered on zero. Left hippocampus overall model (R = 0.495, p < 0.0001); right hippocampus overall model (R = 0.533, p < 0.0001)
^a n = 524 after exclusions

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ISSN: 1758-9193

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