Skip to main content

Table 3 Summary of regression moderation analyses for left and right hippocampal volume outcomes (n = 526)

From: Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume

  Left hippocampusa Right hippocampusa
Variable β Coefficient p Value 95% CI β Coefficient p Value 95% CI
Amyloid PET positivity −77.566 0.092 −167.751 12.619 −104.569 0.021 −192.943 −16.195
Diagnosis −246.297 <0.0001 −328.569 164.024 −249.308 <0.0001 −333.037 165.578
Sex −54.713 0.193 −137.229 27.802 −66.609 0.111 −148.498 15.28
A+ × diagnosis × sex −57.528 0.726 −380.114 265.058 −276.81 0.089 −596.41 42.789
A+ × diagnosis −137.015 0.094 −297.34 23.309 −123.397 0.127 −281.968 35.173
A+ × sex 90.467 0.259 −66.718 247.652 77.968 0.329 −78.934 234.869
Diagnosis × sex −61.618 0.454 −223.256 100.021 −135.762 0.097 −296.177 24.654
Age −26.758 <0.0001 −32.976 20.539 −30.667 <0.0001 −36.752 −24.583
Education 0.312 0.969 −15.337 15.962 −8.534 0.281 −24.0581 6.989
Modified MoCA 34 0.001 13.599 54.4 31.479 0.003 10.901 52.057
APOE ε4 carrier status −15.354 0.742 −107.004 76.297 −29.992 0.513 −120.083 60.099
  1. Abbreviations: A + Florbetapir positron emission tomography amyloid positivity, APOE Apolipoprotein E, MoCA Montreal Cognitive Assessment, PET Positron emission tomography
  2. Age, education, and modified MoCA scores were centered at their means. Dichotomous variables were centered on zero. Left hippocampus overall model (R = 0.495, p < 0.0001); right hippocampus overall model (R = 0.533, p < 0.0001)
  3. a n = 524 after exclusions