Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume

Table 2 Summary of regression moderation analyses for Rey Auditory Verbal Learning Test Verbal Learning and Free Recall memory test outcomes (n = 742)

	RAVLT Total Learning score^a				RAVLT Delayed Free Recall score^b
	β Coefficient	p Value	95% CI		β Coefficient	p Value	95% CI
Amyloid PET positivity	−2.766	0.001	−4.321	−1.21	−1.056	0.001	−1.689	−0.422
Diagnosis	−5.586	<0.0001	−7.122	−4.05	−1.791	<0.0001	−2.404	−1.178
Sex	6.308	<0.0001	4.804	7.812	1.854	<0.0001	1.245	2.463
A⁺ × diagnosis × sex	−6.616	0.025	−12.385	−0.847	−2.116	0.073	−4.431	0.199
A⁺ × diagnosis	−1.486	0.314	−4.382	1.411	−0.536	0.359	−1.683	0.611
A⁺ × sex	0.229	0.877	−2.677	3.135	−0.623	0.288	−1.773	0.528
Diagnosis × sex	0.689	0.639	−2.19	3.567	−0.562	0.341	−1.717	0.594
Age	−0.371	<0.0001	−0.473	−0.268	−0.095	<0.0001	−0.137	−0.053
Education	0.388	0.003	0.134	0.643	0.114	0.035	0.008	0.221
Modified MoCA	1.357	<0.0001	1.002	1.711	0.404	<0.0001	0.279	0.53
APOE ε4 carrier status	−1.713	0.0259	−3.219	−0.207	−0.817	0.008	−1.424	−0.211

Abbreviations: A ⁺ Florbetapir positron emission tomography amyloid positivity, APOE Apolipoprotein E, MoCA Montreal Cognitive Assessment, PET Positron emission tomography, RAVLT Rey Auditory Verbal Learning
Age, education, and modified MoCA score were centered at their means. Dichotomous variables were centered on zero (RAVLT total learning score overall model, R = 0.623, p < 0.0001; RAVLT Delayed Free Recall score overall model, R = 0.522, p < 0.0001)
^a n = 739 after exclusions
^b n = 741 after exclusions

ISSN: 1758-9193