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Table 1 Sample characteristics by diagnosis, sex, and amyloid status

From: Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume

  Normal cognition Early mild cognitive impairment
  Female (n = 154) Male (n = 131) Female (n = 205) Male (n = 252)
  Florbetapir-negative Florbetapir-positive Florbetapir-negative Florbetapir-positive Florbetapir-negative Florbetapir-positive Florbetapir-negative Florbetapir-positive
Demographics
 No. of subjects 91 63 100 31 93 112 114 138
 Age, years 70.8 (5.6) 72.4 (5.0) 72.3 (6.2) 77.8 (5.8) 69.5 (8.3) 70.8 (7.1) 69.2 (7.4) 73.7 (6.4)
 Education, years 16.5 (2.5) 15.5 (2.6) 17.2 (2.3) 17.6 (2.4) 15.8 (2.3) 15.6 (2.8) 16.8 (2.5) 16.5 (2.7)
 White, % 92.3 93.7 89 87.1 90.3 92 92.1 96.4
 Hispanic, % 8.8 4.8 3 0 6.5 3.6 3.5 2.2
Cognition
 Modified MoCA 23.5 (1.6) 22.3 (1.7) 23.4 (1.7) 23.0 (1.6) 22.6 (2.1) 21.8 (2.4) 22.6 (2.0) 21.9 (2.5)
 RAVLT Total Learning 48.8 (8.9) 47.0 (8.3) 44.4 (11.5) 37.7 (8.8) 45.0 (11.6) 37.6 (10.7) 37.2 (9.9) 32.0 (8.9)
 RAVLT Delayed Recall 8.9 (3.4) 7.8 (3.6) 7.0 (4.5) 5.2 (3.1) 7.4 (4.5) 4.3 (4.2) 5.0 (3.7) 3.5 (3.2)
Brain volumea
 No. of subjects 59 34 70 16 77 84 86 100
 Left, raw, mm3 3640.458 (408.312) 3626.059 (451.953) 3891.829 (495.200) 3716.563 (338.556) 3530.481 (502.509) 3339.369 (516.286) 3724.186 (579.737) 3438.300 (541.483)
 Right, raw, mm3 3727.322 (444.720) 3718.941 (450.135) 3991.514 (460.636) 3712.375 (348.348) 3631.662 (493.285) 3338.345 (552.385) 3822.256 (612.419) 3562.970 (500.952)
 Total ICV, raw, mm3 1.41 × 106 (102,176.7) 1.41 × 106 (122,896.4) 1.57 × 106 (135,998.0) 1.58 × 106 (151,662.0) 1.42 × 106 (121,471.7) 1.41 × 106 (108,602.5) 1.58 × 106 (127,438.3) 1.61 × 106 (149,837.7)
APOE ε4 carrier status
 ε4 allele carriers, n 23 29 17 15 19 76 32 93
  1. Abbreviations: APOE Apolipoprotein E, ICV Intracranial volume, MoCA Montreal Cognitive Assessment, RAVLT Rey Auditory Verbal Learning Test
  2. Mean (SD) data are shown for continuous variables
  3. a For brain volume analyses, females with normal cognition (n = 93), males with normal cognition (n = 86), females with early mild cognitive impairment (n = 161), and males with early mild cognitive impairment (n = 186)