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Table 2 Regions in which decreased gray matter volume is associated with progression to dementia in subjects with MCI

From: Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment

Cluster size MNI peak coordinates Hazard ratio Region
x y z
59,330 –9 30 –25.5 1.78 Left rectal gyrus
43.5 1.5 6 1.78 Right insula
–21 –34.5 –4.5 1.75 Left hippocampus
27 –25.5 –15 1.70 Right parahippocampal gyrus
57 –37.5 –7.5 1.69 Right middle temporal gyrus
25.5 25.5 46.5 1.66 Right middle frontal gyrus
–39 30 6 1.63 Left inferior frontal gyrus
–54 0 –1.5 1.61 Left superior temporal gyrus
1.5 42 –6 1.60 Right anterior cingulate
16.5 42 34.5 1.59 Right medial frontal gyrus
2571 7.5 –31.5 40.5 1.67 Right cingulate gyrus
10.5 –58.5 36 1.58 Right precuneus
797 39 –46.5 39 1.57 Right inferior parietal lobule
679 45 –70.5 –6 1.68 Right inferior temporal gyrus
540 –55.5 –54 36 1.42 Left supramarginal gyrus
  1. Presented are the anatomical details of the five largest clusters. For the large clusters, several local maxima spread across the cluster are given
  2. MCI mild cognitive impairment; MNI: montreal neurological institute space