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Table 2 Regions in which decreased gray matter volume is associated with progression to dementia in subjects with MCI

From: Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment

Cluster size

MNI peak coordinates

Hazard ratio

Region

x

y

z

59,330

–9

30

–25.5

1.78

Left rectal gyrus

43.5

1.5

6

1.78

Right insula

–21

–34.5

–4.5

1.75

Left hippocampus

27

–25.5

–15

1.70

Right parahippocampal gyrus

57

–37.5

–7.5

1.69

Right middle temporal gyrus

25.5

25.5

46.5

1.66

Right middle frontal gyrus

–39

30

6

1.63

Left inferior frontal gyrus

–54

0

–1.5

1.61

Left superior temporal gyrus

1.5

42

–6

1.60

Right anterior cingulate

16.5

42

34.5

1.59

Right medial frontal gyrus

2571

7.5

–31.5

40.5

1.67

Right cingulate gyrus

10.5

–58.5

36

1.58

Right precuneus

797

39

–46.5

39

1.57

Right inferior parietal lobule

679

45

–70.5

–6

1.68

Right inferior temporal gyrus

540

–55.5

–54

36

1.42

Left supramarginal gyrus

  1. Presented are the anatomical details of the five largest clusters. For the large clusters, several local maxima spread across the cluster are given
  2. MCI mild cognitive impairment; MNI: montreal neurological institute space