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Table 1 Subject characteristics according to progression and amyloid status

From: Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment

Characteristic

All subjects (n = 276)

Amyloid negative (n = 116)

Amyloid positive (n = 160)

Stable

Progression

Stable

Progression

Stable

Progression

Number of subjects

154 (56)

122 (44)

93 (80)

23 (20)

61 (38)

99 (62)

Age (years)

65.5 ± 7.7

68.3 ± 8.1*

63.8 ± 7.9

68.2 ± 8.7

68.2 ± 6.5

68.3 ± 8.0

Male gender

97 (63)

67 (56)

64 (69)

16 (70)

33 (54)

51 (51)

Education

5.0 ± 1.5

4.9 ± 1.7

4.8 ± 1.7

5.0 ± 1.6

5.3 ± 1.2

4.9 ± 1.7

MMSE

27.0 ± 2.2

26.1 ± 2.6*

27.0 ± 2.2

26.6 ± 2.5

27.0 ± 2.2

26.0 ± 2.6

CSF Aβ1–42

794 ± 307

534 ± 194*

999 ± 207

848 ± 172*

481 ± 104

462 ± 107

WMH (Fazekas)

0.99 ± 0.92

1.03 ± 0.80

0.88 ± 0.93

1.30 ± 1.02

1.15 ± 0.89

0.97 ± 0.73

NGMV

0.41 ± 0.04

0.39 ± 0.05*

0.42 ± 0.04

0.39 ± 0.06*

0.41 ± 0.04

0.39 ± 0.04

Follow-up (years)

2.5 ± 1.5

2.6 ± 1.7

2.3 ± 1.4

2.8 ± 2.0

2.7 ± 1.7

2.6 ± 1.3

Follow-up diagnosis

 AD

104 (85)

10 (43)

94 (95)

 DLB

3 (2)

2 (9)

1 (1)

 FTD

4 (3)

3 (13)

1 (1)

 VaD and mixed

9 (7)

6 (26)

3 (3)

 Other

2 (2)

2 (9)

0 (0)

  1. Data presented as mean ± SD or count (%)
  2. AD Alzheimer’s disease, CSF cerebrospinal fluid, DLB Lewy body dementia, FTD fronto-temporal dementia, MMSE Mini-Mental state examination, NGMV normalized gray matter volume, VaD vascular dementia, WMH white matter hyperintensities measured with 4-point Fazekas scale
  3. *p < 0.01 different from stable subjects
  4. p < 0.05 different from stable subjects