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Table 4 Brain phospholipids (percentage of measured phospholipids for each class) among male mice fed oleic acid-enriched or arachidonic acid-enriched diet

From: Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance

Brain structures Cortex Hippocampus
Injections NaCl 42 NaCl 42
Diets OLE ARA OLE ARA OLE ARA OLE ARA
Phosphatidylinositol
 16:0/20:4 13.10 ± 1.83 13.69 ± 0.33 7.80 ± 0.49a 8.28 ± 0.17a 10.90 ± 0.49 10.49 ± 0.66 8.08 ± 2.24 7.04 ± 0.21
 18:0/20:4 74.30 ± 1.74 76.34 ± 1.37 87.32 ± 1.53b 87.22 ± 0.44b 78.38 ± 0.56 78.17 ± 0.93 83.32 ± 3.22 83.49 ± 0.54
 18:1/20:4 9.27 ± 0.23 7.81 ± 0.97 2.95 ± 1.09b 3.06 ± 0.30a 9.16 ± 0.32 9.77 ± 0.52 7.61 ± 0.83 7.61 ± 0.42
 16:0/22:6 1.07 ± 0.16 0.18 ± 0.04c 0.18 ± 0.01d 0.22 ± 0.03 0.58 ± 0.02 0.53 ± 0.04 0.48 ± 0.05 0.64 ± 0.01
 18:0/22:6 2.26 ± 0.40 1.98 ± 0.25 1.75 ± 0.08 1.22 ± 0.06 0.99 ± 0.09 1.04 ± 0.18 0.51 ± 0.13 1.22 ± 0.74
 Arachidonic acid species 96.67 ± 0.57 97.84 ± 0.21 98.07 ± 0.07 98.56 ± 0.06 98.43 ± 0.08 98.42 ± 0.17 99.01 ± 0.17 98.14 ± 0.75
 Docosahexaenoic acid species 3.33 ± 0.57 2.16 ± 0.21 1.93 ± 0.07 1.44 ± 0.06 1.57 ± 0.08 1.58 ± 0.17 0.99 ± 0.17 1.86 ± 0.75
 Phosphatidylcholine
 16:0/20:4 45.18 ± 4.90 49.97 ± 2.51 45.35 ± 1.57 53.01 ± 2.76 26.94 ± 1.44 28.66 ± 1.42 68.63 ± 1.96b 63.14 ± 9.83a
 18:0/20:4 16.75 ± 3.75 15.2 ± 2.63 27.70 ± 2.36 26,79 ± 1.59 35.68 ± 0.24 37.78 ± 1.18 16.35 ± 2.13a 15.05 ± 6.23b
 18:1/20:4 2.92 ± 0.76 3.38 ± 0.65 5.55 ± 0.95 3.69 ± 0.22 10.29 ± 0.61 10.23 ± 0.71 2.62 ± 0.28d 4.83 ± 0.94b
 18:0/22:6 16.29 ± 1.27 16.30 ± 1.56 1.02 ± 0.07d 2.45 ± 0.50d 9.05 ± 0.83 7.16 ± 0.57 5.19 ± 0.83 6.81 ± 1.35
 18:1/22:6 8.22 ± 1.40 6.80 ± 0.86 0.91 ± 0.15b 1.40 ± 0.22a 3.04 ± 0.36 2.90 ± 0.05 3.84 ± 0.47 3.10 ± 0.07
 16:0/22:6 10.64 ± 3.33 8.43 ± 1.81 19.47 ± 0.25 12.65 ± 1.95 15.00 ± 1.33 13.27 ± 0.37 3.37 ± 1.33d 7.07 ± 1.37a
 Arachidonic acid species 64.85 ± 0.80 68.46 ± 1.04 78.60 ± 0.15d 83.49 ± 1.45d 72.91 ± 2.09 76.67 ± 0.97 87.61 ± 0.14b 83.02 ± 2.66
 Docosahexaenoic acid species 35.15 ± 0.80 31.54 ± 1.04 21.40 ± 0.15d 16.51 ± 1.45d,e 27.09 ± 2.09 23.33 ± 0.97 12,39 ± 0.14b 16.98 ± 2.66
Phosphatidylserine
 18:0/20:4 3.18 ± 0.26 11.16 ± 0.35c 1.47 ± 0.08b 1,92 ± 0.07d 6.17 ± 0.23 7.12 ± 0.40 3.70 ± 0.16b 5.36 ± 0.37a,e
 16:0/22:4 0.13 ± 0.02 0.17 ± 0.01 0.21 ± 0.01 0.22 ± 0.03 0.21 ± 0.02 0.26 ± 0.03 0.077 ± 0.010b 0.093 ± 0.009b
 18:0/22:4 6.35 ± 0.26 9.11 ± 0.18c 5.41 ± 0.14 9.10 ± 0.35c 7.73 ± 0.36 10.57 ± 0.03 6.31 ± 0.32 10.75 ± 1.35e
 18:1/22:5 0.43 ± 0.07 0.46 ± 0.01 0.38 ± 0.08 0,45 ± 0.02 0.41 ± 0.02 0.48 ± 0.06 0,41 ± 0.04 0.44 ± 0.01
 18:0/22:6 89.91 ± 0.40 79.10 ± 0.53c 92.53 ± 0.19a 88.32 ± 0.40c,d 85.49 ± 0.58 81.57 ± 0.43 89.50 ± 0.46 83.35 ± 1.69e
Phosphatidylethanolamine
 a16:0/20:4 3.23 ± 0.04 4.04 ± 0.07 1.70 ± 0.24b 2.80 ± 0.16b,e 3.51 ± 0.09 4.17 ± 0.15 2.74 ± 0.13 4,54 ± 0.99
 p16:0/20:4 3.58 ± 0.19 4.02 ± 0.04 1.06 ± 0.01d 2.39 ± 0.14c,d 2.41 ± 0.28 2.39 ± 0.16 1.59 ± 0.08 2,67 ± 0.51
 a18:0/20:4 18.29 ± 1.66 16.97 ± 0.26 18.03 ± 0.16 19.38 ± 0.44 20.52 ± 0.36 21.31 ± 0.96 22.66 ± 0.65 13.57 ± 5.29
 p18:0/20:4 4.70 ± 0.19 5.78 ± 0.24 5.12 ± 0.24 6.43 ± 0.09e 4.45 ± 0.31 5.02 ± 0.30 4.93 ± 0.19 8.68 ± 1.91
 a18:1/20:4 2.22 ± 0.11 2.38 ± 0.06 0.41 ± 0.09d 0.84 ± 0.08d,e 2.47 ± 0.06 2.84 ± 0.03 1.18 ± 0.07b 1.17 ± 0.36b
 p18:1/20:4 2.79 ± 0.18 3.20 ± 0.08 1.21 ± 0.23b 2.13 ± 0.10b,e 2.50 ± 0.17 2.87 ± 0.21   4.22 ± 0.95
 a18:2/20:4 0.03 ± 0.01 0.04 ± 0.005 0.02 ± 0.001 0.02 ± 0.003 0 0 0.025 ± 0.001b 0.014 ± 0.010
 p18:2/20:4 0.04 ± 0.004 0.03 ± 0.004 0.02 ± 0.004 0.02 ± 0.002 0.048 ± 0.007 0 0.032 ± 0.004b 0.031 ± 0.008a
 p16:0/22:4 3.15 ± 0.14 3.76 ± 0.15 2,91 ± 0.24 4,29 ± 0.08f 3.12 ± 0.33 3.71 ± 0.13 3.67 ± 0.05 6.13 ± 1.29
 p16:1/22:4 0 0.01 ± 0.00 0.0015 ± 0.0007 0.0029 ± 0.0003b 0 0 0.0033 ± 0.0005 0,006 ± 0.0016a
 a18:0/22:4 3.97 ± 0.41 4.51 ± 0.24 1.55 ± 0.06d 2.25 ± 0.11b 3.02 ± 0.01 3.78 ± 0.29 1.94 ± 0.11 4.34 ± 0.71e
 a18:1/22:4 0.21 ± 0.01 0.26 ± 0.01e 0.10 ± 0.01d 0.20 ± 0.002a,c 0.22 ± 0.06 0.28 ± 0.01 0.17 ± 0.01 0,35 ± 0.08e
 a18:0/22:5 7.13 ± 0.57 7.20 ± 0.09 5.19 ± 0.21a 5.85 ± 0.12 4.47 ± 0.15 5.23 ± 0.10 5.26 ± 0.09 6,67 ± 1.70
 a16:0/22:6 7.10 ± 0.14 6.24 ± 0.06f 4.03 ± 0.06d 3.71 ± 0.06d 5.89 ± 0.01 5.49 ± 0.24 3.85 ± 0.05 1.12 ± 0.80b,e
 p16:0/22:6 6.02 ± 0.15 4.69 ± 0.14f 3.62 ± 0.17d 2.74 ± 0.06d,e 4.90 ± 0.40 5.46 ± 0.09 4.29 ± 0.21 4,90 ± 0.72
 a18:0/22:6 28.25 ± 3.25 22.01 ± 0.55 25.14 ± 0.42 22.31 ± 0.06 20.70 ± 0.42 17.94 ± 0.37 22.28 ± 0.27 23.27 ± 6.20
 p18:0/22:6 11.76 ± 1.53 10.31 ± 0.51 16,14 ± 0.46 13.10 ± 0.61 16.72 ± 1.60 14.60 ± 0.99 17.65 ± 1.01 9,16 ± 3.54
 a18:1/22:6 2.03 ± 0.29 1.36 ± 0.05 12.66 ± 1.05d 10.33 ± 0.79d 1.55 ± 0.16 1.27 ± 0.04 5,32 ± 1.00b 1,18 ± 0.23f
 p18:1/22:6 3.34 ± 0.13 3.19 ± 0.16 1.11 ± 0.23d 1.19 ± 0.08d 4.13 ± 0.31 3.64 ± 0.22 2,43 ± 0.37 1.61 ± 0.55a
 Arachidonic acid species 30.11 ± 3.0 36.46 ± 0.09 27.56 ± 0.94 34.02 ± 0.69 35.92 ± 0.44 38.60 ± 1.27 33,16 ± 0.32 41.28 ± 6.36
 Docosahexaenoic acid species 56.49 ± 3.17 47.80 ± 0.24e 62,69 ± 0.93 53,39 ± 0.73e 53.25 ± 0.95 48.40 ± 1.35 55.81 ± 0.33 41.23 ± 2.85f
 Docosatetraenoic acid species 6.27 ± 0.64 8.53 ± 0.11e 4,56 ± 0.21 6.74 ± 0.16a,e 6.36 ± 0.36 7.77 ± 0.27 5.78 ± 0.08 10.83 ± 2.07
 Docosapentaenoic acid species 7.13 ± 0.57 7.20 ± 0.09 5,19 ± 0.21a 5.85 ± 0.12 4.47 ± 0.15 5.23 ± 0.10 5.26 ± 0.09 6.67 ± 1.70
  1. 42 Amyloid-β peptide 42, ARA Arachidonic acid-enriched diet, OLE Oleic acid-enriched diet
  2. a p < 0.05, Aβ42 compared with NaCl
  3. b p < 0.01, Aβ42 compared with NaCl
  4. c p < 0.001, ARA compared with OLE
  5. d p < 0.001, Aβ42 compared with NaCl
  6. e p < 0.05, ARA compared with OLE
  7. f p < 0.01, ARA compared with OLE