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Table 3 Cortex and hippocampus fatty acid composition (%) in mice fed oleic acid-enriched or arachidonic acid-enriched diet

From: Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance

  Cortex Hippocampus
  OLE ARA OLE ARA
Palmitic acid (16:0) 26.92 ± 0.07 27.04 ± 0.11 25.23 ± 0.14 24.76 ± 0.23
Stearic acid (18:0) 24.93 ± 0.19 25.17 ± 0.09 26.03 ± 0.18 25.72 ± 0.37
Palmitoleic acid (16:1) 0.40 ± 0.00 0.39 ± 0.01 0.43 ± 0.01 0.41 ± 0.00
Oleic acid (18:1) 12.13 ± 0.06 11.52 ± 0.06a 12.68 ± 0.16 11.61 ± 0.13a
Linoleic acid (18:2 ω-6) 0.61 ± 0.01 0.38 ± 0.02b 0.61 ± 0.02 0.34 ± 0.02a
Arachidonic acid (20:4 ω-6) 11.50 ± 0.03 12.69 ± 0.05b 13.08 ± 0.15 14.65 ± 0.23a
Docosatetraenoic acid (22:4 ω-6) 3.71 ± 0.02 4.75 ± 0.04b 4.76 ± 0.15 5.82 ± 0.09b
Linolenic acid (18:3 ω-3) LOQ LOQ 0.05 ± 0.05 0.02 ± 0.02
Eicosapentaenoic acid (20:5 ω-3) LOQ LOQ LOQ LOQ
Docosahexaenoic acid (22:6 ω-3) 19.81 ± 0.06 18.04 ± 0.10b 17.14 ± 0.26 16.68 ± 0.38
Sum of ω-6 PUFA 15.82 17.82 18.44 20.81
Sum of ω-3 PUFA 19.81 18.07 17.19 16.69
  1. Abbreviations: ARA Arachidonic acid-enriched diet, OLE Oleic acid-enriched diet, LOQ Limit of quantitation PUFA Polyunsaturated fatty acid
  2. a p < 0.05, ARA compared with OLE. n = 8 in OLE diet group, n = 12 in ARA diet group
  3. b p < 0.001, ARA compared with OLE. n = 8 in OLE diet group, n = 12 in ARA diet group