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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance

Fig. 5

Modification of hippocampal and cortical synaptic postsynaptic density protein 95 (PSD95) induced by arachidonic acid-enriched (ARA) diet. Immediately after the probe test, mice were killed, and synaptosomes were prepared from the cortex and hippocampus. Representative immunoblots of cortical (a) and hippocampal (b) PSD95 from oleic acid-enriched (OLE) or ARA diet mice after NaCl or amyloid-β peptide (Aβ42) injections are shown. Densitometric analyses were performed to determine signal intensities normalized to β-tubulin, and data are expressed as percentages of control OLE mice given injections with NaCl (* p < 0.05, comparing the four groups of mice). Results are shown as mean ± SEM of immunoblots performed for all animals (OLE groups, n = 4; ARA groups, n = 6)

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Alzheimer's Research & Therapy

ISSN: 1758-9193