EOAD | LOAD | |||||
---|---|---|---|---|---|---|
Percentage of variance accounted for, all fixed terms | 53.6%, p < 0.001 | 55.3%, p < 0.001 | ||||
Significant predictors in final mixed models | β Value | 95% CI | p Value | β Value | 95% CI | p Value |
Fixed terms | ||||||
Intercept | 16.592 | 7.605, 25.579 | < 0.001 | −28.833 | −47.874, −9.793 | 0.003 |
Time in months from baseline | −0.352 | −0.729, 0.026 | 0.067 | −0.228 | −0.397, −0.060 | 0.008 |
ADAS-Cog score at baseline | 0.708 | 0.567, 0.849 | < 0.001 | 2.688 | 1.838, 3.538 | < 0.001 |
Time in months × ADAS-Cog score at baseline | 0.022 | 0.013, 0.030 | < 0.001 | 0.022 | 0.018, 0.026 | < 0.001 |
Background variables | ||||||
Sex (male = 0, female = 1) | NS | −2.177 | −4.525, 0.171 | 0.069 | ||
Sex × ADAS-Cog score at baseline | NS | 0.150 | 0.043, 0.257 | 0.006 | ||
Age at first assessment, years | NS | 0.422 | 0.175, 0.668 | 0.001 | ||
Age × ADAS-Cog score at baseline | NS | −0.026 | −0.037, −0.015 | < 0.001 | ||
Education, years | −0.569 | −1.091, −0.047 | 0.033 | −0.073 | −0.275, 0.129 | 0.478 |
Time in months × education, years | 0.041 | 0.009, 0.073 | 0.013 | 0.016 | 0.002, 0.030 | 0.029 |
IADL score at baseline | NS | 0.273 | 0.175, 0.371 | < 0.001 | ||
ChEI dosea | −0.097 | −0.183, −0.011 | 0.027 | −0.045 | −0.070, −0.021 | < 0.001 |
Random terms (variance) | ||||||
Intercept | 32.457 | 21.150, 49.808 | < 0.001 | 13.012 | 10.010, 16.915 | < 0.001 |
Time in months | 0.145 | 0.096, 0.221 | < 0.001 | 0.103 | 0.086, 0.124 | < 0.001 |