Fig 2

Global outcome over 3 years of cholinesterase inhibitor (ChEI) treatment. The proportion of patients is shown according to differences in treatment response in global performance (Clinician Interview-Based Impression of Change (CIBIC)) from the start of ChEI therapy over 3 years for early-onset Alzheimer’s disease (EOAD) versus late-onset Alzheimer’s disease (LOAD). No significant differences in global response were observed between the two groups, except after 24 months (p = 0.005) of treatment. CIBIC scores 1–3 were considered as improvement, 4 as unchanged, and 5–7 as deterioration